Just about everyone I know seems to be ranting about it. Barely a day goes by without someone telling me how much they love it, how "it totally gets my nerdy sense of humour!" or "it's a show for smart people like me yay!"
From what I've seen the show mainly laughs at nerds/nerd culture, rather than with them. It constantly implies that Leonard/Howard/that guy at the comic book shop are utterly miserable and pathetic because they like comics or whatever, and makes Sheldon seem borderline autistic. I haven't once seen an instance in which the audience are invited to laugh with one of the main cast about something considered nerdy or geeky; the joke seems to be that someone is pathetic enough to know/make a joke about that in the first place.
Not to mention all of the science mentioned is incredibly basic. The writers seem to think that namedropping Richard Feynman and string theory makes the programme "high-brow". The Sheldon gags are particularly hideous; how many times has 'socially awkward genius' been done before? The acting is wooden, the screenplay is crass and not nearly as clever as it thinks, and if I had any interest in comics/computer programming/other things taken the piss out of, I'd probably be offended by it.
Does anyone else agree?