I've only done 3 drugs; Weed, Poppers and Mephadrone (Not Meth)
Poppers where boring, picked them up at a festival to see what they were like.
Weed never did much for me really. As I started to generally smoke a bit more It would have a nice calming affect but nothing more.
Now Mephadrone. I did this when it was still legal and it was pretty good. It gave you a very nice buzz, and didn't ever make me feel ill or like there was something wrong. The comedown was just that you would become a bit more quiet than you had been (as most people I met who had it along with me would just generally have the buzz and talk a lot more than usual)
In general I don't do drugs just because I can't easily get a hold of them and I don't socialize too much so i'd end up just doing them myself and that would be pretty pointless.