Here are the ones I think of:
Kurt Russell + Viggo Mortensen = Brothers... no... CLONES.
Matt Damon + Mark Wahlberg = Brothers
Matt Damon/Mark Wahlberg + Kevin Bacon = Father and sons
Jodie Foster + Helen Hunt = Sisters
Helen Hunt + Leelee Sobieski = Mother and daughter
Chevy Chase + Will Ferrell = Father and son, without a doubt.
Robert Downey Jr. + That bloke from Emmerdale + J.D. from Scrubs' brother = Brothers
George Wendt + John Goodman = Brothers.
Alfred Molina + That bloke from Scrubs = Brothers
Ed Norton + Josh Stewart = Brothers
Ed Norton/Josh Stewart + Kevin Spacey = Father and sons
Ed Norton/Josh Stewart/Kevin Spacey + Robert Lindsay = Uncle and brother to the other lot
Thin Jonah Hill + Drew Carey = Father and Son
Randy Couture + Jason Statham = Cousins (part-way through The Expendables, I forgot Couture was in it and thought I was still watching Statham)
Lauren Bacall + Laura Prepon = Mother and daughter
Made In Dagenham's Sally Hawkins + Dagenham's Stacey Solomon = Sisters (I know Stacey's not an actor, but 'Made In Dagenham'? On a plate.)
Carrie Fisher + Jessica Hecht + Alanis Morissette (hey, she played GOD) + Hilary S**** + Jane Leeves = Some combination of mother/daughter/sister
I know there was another film I saw that I truly thought was starring someone else. Shame I can't remember it.
Does anyone know of a male/female combination?
Actors who could play/could've played relatives (please contribute)
Elijah Wood Daniel Radcliffe and Tobey Macguire could play brothers. In fact you could probably stick Jake Gyllenhaal in there as well.
Jennifer Garner and Hillary S**** could play sisters
Leonardo Dicaprio and Matt Damon
Ah, beaten to it. Natalie Portman and Keira Knightly do look very similar.
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