Women are just as capable as men are when it comes to playing superspies (thinking of Alias specifically) but James Bond should stay James, not become Jane imo. I think it would take a way a lot more than it would add to the franchise
I'd worry that if it did happen then 90% of reviewers would focus upon the gender, and not the performance overall. The same thing happened to Helen Mirren when she played Prospera in The Tempest and it annoyed me to no end.