here is a summary of smoking:
nicotine -
nicotine causes the release of adrenaline which increases the heart, breathing rate and causes constriction of the arterioles. This increases the blood pressure which can damage the lining of the artieries. The damage attracts phagocytes which encourage the growth of smooth muscle and deposition of fatty substances. More fats are deposited in the wall of the artery. Artheromas form which can form plaques that restrict the lumen of the coronary arteries. This is atherosclerosis. This can lead to coronary heart disease as less blood flows to cardiac muscle and the cardiac muscle receives less oxygen for respiration.
Nicotine can also increase the risk of coronary heart disease as it makes platelets sticky which increases the risk of blood clots forming. blood clots in the coronary arteries restricts the flow of blood in the arteries and restricts blood flow to cardiac muscle, so the cardiac muscle receives less oxygen for respiration, therefore death of the cardiac muscle.
carbon monoxide can also increase the risk of coronary heart disease
carbon monoxide damages the lining of the arteries which causes more fats to be deposited in the walls of the arteries and fatty deposits called artheromas form. This leads to atherosclerosis and reduces the lumen of the artery, restricting blood flow to cardiac muscle
also carbon monoxide enters red blood cells and combines with HB to form carboxyhaemoglobin which reduces oxygen carrying capaciy of blood so cardiac muscle recieves less oxygen.
nicotine and carbon monoxide also increases the risk of having a stroke