[graemematt]

(Original post by John Locke)
NMDA is overrated, there are many types of synaptic plasticity that have no requirement for NMDA activation (including LTP).

Tech, you're forgetting post-transcriptional and post-translational modification which can change a protein's conformation without altering DNA.

Wangers, your protein model needs to account for retrieval.

Not gonna lie...I really don't miss pre-clinical medicine and its intricacies

[Kinkerz]

"Stop! Control yourself, Upton. I've spent the last hour teaching you how to examine a patient. It obviously hasn't percolated through to that atrophied conglomerate of malformed neurons you use for a brain that you ask questions first!"

Brilliant.

[Elwyn]

(Original post by Kinkerz)


"Stop! Control yourself, Upton. I've spent the last hour teaching you how to examine a patient. It obviously hasn't percolated through to that atrophied conglomerate of malformed neurons you use for a brain that you ask questions first!"

Brilliant.

Nothing beats classic comedy.
My personal favourite clip: http://m.youtube.com/watch?v=oVWjAeAa52o

[RollerBall]

I have a bit of a dilemma. As some of you know (from my constant bitching) I've had a bit of personal trouble as of late wrt my other half. Don't worry, this is at least semi-related to medicine! I have a pastoral meeting tomorrow with my tutor and I was wondering if it's worth bringing it up? I've had real trouble keeping my head down in work because of it over the past two weeks or so and as such I've really ****ed myself over for some up coming deadlines. On the one hand I feel like it's relevent and what this pastoral support is there for. On the other hand I feel like it's not a major problem and I'm just being a fanny about it.

Advice?

[SMed]

My apologies Rollerball, the following image is poorly and insensitively timed, but has nothing to do with your unfortunate recent events. I wish you all the best.

But this lol'd me:

[SMed]

(Original post by RollerBall)
I have a bit of a dilemma. As some of you know (from my constant bitching) I've had a bit of personal trouble as of late wrt my other half. Don't worry, this is at least semi-related to medicine! I have a pastoral meeting tomorrow with my tutor and I was wondering if it's worth bringing it up? I've had real trouble keeping my head down in work because of it over the past two weeks or so and as such I've really ****ed myself over for some up coming deadlines. On the one hand I feel like it's relevent and what this pastoral support is there for. On the other hand I feel like it's not a major problem and I'm just being a fanny about it.

Advice?

I would probably leave it at 'personal problems at home' and only if asked, explain things further.

[RollerBall]

(Original post by SMed)
I would probably leave it at 'personal problems at home' and only if asked, explain things further.

Yeah, I think I'm going to. I just broke up with her actually, turns out she cheated on me twice so that's it. I'm out, I deserve better. Hey, I'm only 19 at the end of the day.

[rumandraisin]

(Original post by RollerBall)
Yeah, I think I'm going to. I just broke up with her actually, turns out she cheated on me twice so that's it. I'm out, I deserve better. Hey, I'm only 19 at the end of the day.

Good for you mate. As hard as it is (been in a similar position), you just got to try move on and show her what she messed up on and what she has now lost. But ultimately get on with things and enjoy life!

Regarding your pastoral meeting, personally i'd keep quite about it unless mentioned.

[Wangers]

(Original post by John Locke)
NMDA is overrated, there are many types of synaptic plasticity that have no requirement for NMDA activation (including LTP).

Tech, you're forgetting post-transcriptional and post-translational modification which can change a protein's conformation without altering DNA.

Wangers, your protein model needs to account for retrieval.

Well, firstly, many memories do not need retrival (yes I know that dosn't answer the point).

I think the substrate could code for a basic class requirement - so a house, or a knife, or a group of objects that are significantly distinct in form.

This could however in theory demand an infinate pool of substrate, which is clearly a challenge. I think that in this model for a memory to become stable, it must either represent a fundamental class, or be firnished with at least episodic characteristics. - By that I mean it must be attached to emotional significance, survival benefit or reward potential - kind of like a somatic marker. - you don't for example need to remember all the houses that ever existed, or know about. Memory is by is nature selective.

often we plan events based on past experiences, I think this reinforces the memory state, or raises the preservation value. Hence people can have partial loss - so temporally graded retrograd amnesia, but with preserved romote autobiograpical recall - because these are emotionally or survival critical.

How does this account for recall? Well. triggering of these memories might come from a shift in protein state - which can cascade down neural networks in a amplifier system. Without synthesis, there is potential for instantaneous recall. With the above conditions - you can ONLY recall when enough aspects of the somatic marker have been triggered - this gives potential for refinment of states. It would also account for why closely related things are more easily confused - because you need more identifiers to create and record it as a discrete state. In actual fact all you need is a shift in any state, not especially protein - but I think a protein state can be used to 'hang off' many refinments that account for specific neural combinatorial states that can encode. And once you have encoded the complex memory, there is no need for the basic reference. - so having encoded the concept on my house, you don't need the reference - house. You only need it initially, but not once the memory is formed. This also cuts down on what states are actually needed. Which allows for active degradation of information.

Of course, how does this explain memory deficits? Well if the state is more used, it becomes more stable, and is less likely to be obliterated. How do we explain the differences in distinct episodic or semantic loss? Well whole discrete loss (eg only semantic, but totally preserved episodic ) is rare - usually the two are knocked out together, which suggests thay to some extent they are co-coded - evidence for this comes from Pt VC with almost flat loss of well almost everything.

Can neural states actually encode complex information? Why yes, Place cells can encode just such a thing via a integrated neural network See 2 attached papers.

remember actually the number of states finally needed is very small - after all computers can encode and recall all sorts of things with only a binary system.

Attachment 142639

[Lantana]

(Original post by RollerBall)
I have a bit of a dilemma. As some of you know (from my constant bitching) I've had a bit of personal trouble as of late wrt my other half. Don't worry, this is at least semi-related to medicine! I have a pastoral meeting tomorrow with my tutor and I was wondering if it's worth bringing it up? I've had real trouble keeping my head down in work because of it over the past two weeks or so and as such I've really ****ed myself over for some up coming deadlines. On the one hand I feel like it's relevent and what this pastoral support is there for. On the other hand I feel like it's not a major problem and I'm just being a fanny about it.

Advice?

What's the meeting for? It might be something to use to get them off your back if they are berating you about things, but otherwise it sometimes gets more complicated the more people know. It depends on how much trouble you are in and how much it's affecting you tbh.

[clarusblue]

Been doing some practice tests online and failing pathetically...will someone please reassure me that clinical exams don't need to know much histology, picky anatomy, microbiology etc?

[rumandraisin]

(Original post by clarusblue)
Been doing some practice tests online and failing pathetically...will someone please reassure me that clinical exams don't need to know much histology, picky anatomy, microbiology etc?

Bleurgh histology. They make us do too much of that here!

[Mushi_master]

Wheyyyy all OSCE stations passed, definitely thought I'd messed some up!

[areyouthere?]

(Original post by Mushi_master)
Wheyyyy all OSCE stations passed, definitely thought I'd messed some up!

congrats :

[billet-doux]

(Original post by Mushi_master)
Wheyyyy all OSCE stations passed, definitely thought I'd messed some up!

Well done

[RollerBall]

(Original post by Lantana)
What's the meeting for? It might be something to use to get them off your back if they are berating you about things, but otherwise it sometimes gets more complicated the more people know. It depends on how much trouble you are in and how much it's affecting you tbh.

It's a pastoral tutor we get assigned and have compulsory meetings. She just asks how general life is, workload, housing situation, ensures we have stuff outside of medicine etc.

In the end I was 15 minutes late due to a phonecall with my ex and then my tutor never asked so I never brought it up.

As it stands I'm now writing one of the essays so if I manage to submit it tonight it will only technically be one day late and I'm a third of the way through it currently.

[Philosoraptor]

(Original post by Mushi_master)
Wheyyyy all OSCE stations passed, definitely thought I'd messed some up!

Grats *rep*


I'm actually quite looking forward to the rest of this O&G/Infectious diseases module - I'm on the intro lecture week atm and seems ok.

I'll probably be swallowing these words come the exams in July!

[gozatron]

Writing up some digestive notes when i stumble across a little rant halfway through by the lecturer on Béchamel sauce. He just doesn't get students...

[Wangers]

Have to say this abu Qatarder thing sounds like some muppet in the HOme Office screwed up a deadline - student cramming gone wrong?

[Becca-Sarah]

(Original post by RollerBall)
I have a bit of a dilemma. As some of you know (from my constant bitching) I've had a bit of personal trouble as of late wrt my other half. Don't worry, this is at least semi-related to medicine! I have a pastoral meeting tomorrow with my tutor and I was wondering if it's worth bringing it up? I've had real trouble keeping my head down in work because of it over the past two weeks or so and as such I've really ****ed myself over for some up coming deadlines. On the one hand I feel like it's relevent and what this pastoral support is there for. On the other hand I feel like it's not a major problem and I'm just being a fanny about it.

Advice?

I contemplated telling my supervisor, since he mentioned that my project was about a month behind schedule, that being the month that I spent largely hiding under my duvet and thinking I should get a freaking medal for managing to turn up to lectures, but didn't in the end. It's an awkward thing cos it's like a significant enough event to have disrupted your work and therefore they should know about it, but equally the idea of talking about personal relationships with my sup creeps me out.

You can still mention it even though you didn't in that particular meeting, it's not as if a break-up is just a momentary blip in your personal life. Cosmo magazine (or some equivalent girl trash) reckons it takes a month for every year you were in that relationship to get fully over it, so if you have deadlines coming up then it might be better to give your tutor a heads up that you aren't in the greatest state right now.

Also, re protein - I am loving MyProtein's choc mint flavour. Choc nut was so sickly it nearly made a reappearance.