Courtesy of Game Informer:
-The game is set in the Second Era, in the Interregnum.
-Cyrodiil is ravished by war, and the Imperials aren't doing so well.
-The Tharn family has made a pact with the King of Worms, who has agreed to supplement the Imperial's forces by resurrecting their soldiers. Secretly, Mannimarco is conspiring with Molag Bal, the Daedric Prince of Corruption and Slavery, to take over Mundus.
-Molag Bal is harvesting souls of mortals, and the player is an adventurer whose soul has been taken, allowing them to constantly return to life.
-He's also sent "Dark Anchors" into Tamriel, which drag Mundus into Coldharbour. The Fighters Guild have taken it upon themselves to remove them.
-Three major groups have formed:
*The Aldmeri Dominion, consisting of Altmer, Bosmer, and Khajiit, control Alinor, Elsweyr, and Valenwood.
*The Daggerfall Covenant, consisting of Orcs, Bretons, and Redguards, control High Rock and Hammerfell.
*The Ebonheart Pact, consisting of Dunmer, Argonians, and Nords, control Skyrim, Morrowind, and Black Marsh.
-Time-travel will be featured in the game. In one example, the player puts on some old armor and is put in the owner's role, participating in a battle of long ago.
-Undead werewolves will be featured in the game.
-A werewolf named Faolchu has amassed a werewolf army and has taken over Camlorn, High Rock.
-The Thieves Guild, Dark Brotherhood, Fighters and Mages Guilds are in the game.
-There will at some point be a battle for the Imperial City which is overrun by Daedra, deciding who will rule Tamriel.
-The landscape of Cyrodiil is similar to The Elder Scrolls IV: Oblivion, contradicting established lore somewhat.