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Does mRNA diffuse through nuclear pore

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    Does mRNA diffuse through nuclear pores?
    If not then how does it leave the nucleus
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    It is not diffusion but rather active transport.Just to make it simple , certain proteins called "export proteins" or ' exportins ' bind to the mRNA (which carries nuclear export signals ) within the nucleus.The exportin protein is also bound to Ran-GTP (compare to ATP for simplicity) .The exportin carries the mRNA to the cytoplasm where Ran-GTP disassociates in to Ran-GDP and mRNA is let free from the exportin protein.
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    (Original post by ilovemath)
    Does mRNA diffuse through nuclear pores?
    If not then how does it leave the nucleus
    In simple terms, mRNA exits the the nucleus via the nuclear pores, so it can reach the ribosomes, which are in the cytoplasm / on the RER.
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    (Original post by thegodofgod)
    In simple terms, mRNA exits the the nucleus via the nuclear pores, so it can reach the ribosomes, which are in the cytoplasm / on the RER.
    I mean the mechanism: diffusion/active transport...
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    (Original post by ilovemath)
    I mean the mechanism: diffusion/active transport...
    Ah - I thought you wanted to ask whether mRNA leaves the nucleus via the nuclear pores
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    (Original post by thegodofgod)
    Ah - I thought you wanted to ask whether mRNA leaves the nucleus via the nuclear pores
    so is post #2 correct - i.e: active transport?
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    (Original post by ilovemath)
    so is post #2 correct - i.e: active transport?
    No idea, sorry, we don't go into much detail on the AQA course

    However, all Wikipedia mentions, is:

    (Original post by Wikipedia Link)
    Wikipedia Link Another difference between eukaryotes and prokaryotes is mRNA transport. Because eukaryotic transcription and translation is compartmentally separated, eukaryotic mRNAs must be exported from the nucleus to the cytoplasm. Mature mRNAs are recognized by their processed modifications and then exported through the nuclear pore. In neurons, mRNA must be transported from the soma to the dendrites where local translation occurs in response to external stimuli. Many messages are marked with so-called 'zip codes,' which target their transport to a specific location.
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    (Original post by thegodofgod)
    No idea, sorry, we don't go into much detail on the AQA course
    Yes I do AQA too....never mind...I presume they wont ask it then
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    (Original post by ilovemath)
    Yes I do AQA too....never mind...I presume they wont ask it then
    They won't ask in the Unit 5 section, although it may be good to know as the 'off-spec' material for the synoptic essay

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