A vehicle travelling on a highway could be a public nuisance, but it's unlikely that a single vehicle would qualify. If there were dozens of heavy vehicles going back and forth at all times of the day and night then it would have more chance of being so. For a public nuisance to be actionable by an individual that individual needs to show 'special damage', i.e. in this case that he has suffered loss over and above that suffered by other members of the public who happen to use the highway. Look at, for example, Gillingham Borough Council v Medway (Chatham) Docks - there was no nuisance here but only because the operations of the docks had statutory authority, it doesn't seem to have been questioned that the noise and vibrations would otherwise have been a nuisance.
There could arguably be a private nuisance caused by a vehicle on the highway too but that is much more unlikely. An example might be if a car was parked on the road outside a remote house and then started flashing headlights and beeping horn to disturb the owner of the house. That wouldn't be a public nuisance as only one person would be affected, not a class of people.
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