Wolowitz: If it's "creepy" to use the Internet, military satellites, and robot aircraft to find a house full of gorgeous young models so I can drop in on them unexpected, then fine, I'm "creepy".
It's not a one liner but I ROFL at it every time lol: The rock-paper-scissors-lizard-spock quote xD
Scissors cuts paper, paper covers rock, rock crushes lizard, lizard poisons Spock, Spock smashes scissors, scissors decapitates lizard, lizard eats paper, paper disproves Spock, Spock vaporizes rock, and as it always has, rock crushes scissors.
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Sheldon: At my age do you know how I'm statistically most likely to die? Leonard: At the hands of your room mate? Sheldon: An accident. Leonard: That's how I'm going to make it look.
or
Sheldon: I made tea. Leonard: I don't want tea. Sheldon: I didn't make tea for you. This is my tea. Leonard: Then why are you telling me? Sheldon: It's a conversation starter. Leonard: That's a lousy conversation starter. Sheldon: Oh, is it? We're conversing. Checkmate.
Sheldon: Scissors cuts paper, paper covers rock, rock crushes lizard, lizard poisons Spock, Spock smashes scissors, scissors decapitates lizard, lizard eats paper, paper disproves Spock, Spock vaporizes rock, and as it always has, rock crushes scissors.
Raj: I don't like bugs, okay? They freak me out. Sheldon: Interesting. You're afraid of insects and women. Ladybugs must render you catatonic.