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The synthesis of aspirin...help!

I'm currently doing A2 Chemistry (OCR SALTERS) and for my chemistry individual investigation I need to synthesise aspirin in 3 steps. I'm really struggling to find any relevant information.

All I know is that I'm converting:

1) 2-aminomethylbenzoate to 2-hydroxymethylbenzoate (amine diazotization reaction)
2) 2-hydroxymethylbenzoate to 2-hydroxybenzoic acid (hydrolyse)
3) 2-hydroxybenzoic acid to 2-ethanolyoxybenzoic aci (esterify).

I need to write an aim, background information, plan and variables and risk assessment but I have no clue where to start.
Reply 1
Avatar for krisshP
krisshP
14
Original post by OliviaPlant
I'm currently doing A2 Chemistry (OCR SALTERS) and for my chemistry individual investigation I need to synthesise aspirin in 3 steps. I'm really struggling to find any relevant information.

All I know is that I'm converting:

1) 2-aminomethylbenzoate to 2-hydroxymethylbenzoate (amine diazotization reaction)
2) 2-hydroxymethylbenzoate to 2-hydroxybenzoic acid (hydrolyse)
3) 2-hydroxybenzoic acid to 2-ethanolyoxybenzoic aci (esterify).

I need to write an aim, background information, plan and variables and risk assessment but I have no clue where to start.


This may help you
http://www.thestudentroom.co.uk/showthread.php?t=2093428
http://www.thestudentroom.co.uk/showthread.php?t=630557
Aspirin is acetyl salicylic acid. By making its acetylation u can synthesize aspirin, if u want it in 3 steps its also possible, use any synthetic chemistry book as vogels. It has recommended procedure.

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Reply 3
Avatar for saurabhrai
saurabhrai
The synthesis involves the reaction of salicylic acid and acetic anhydride in the presence of a catalyst, phosphoric acid, H3PO4.

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