I'm currently taking AS Chemistry, well just finished actually.
Out of my subjects, Maths, Computing and Biology, I've found Chemistry the hardest. I found that it was a big step from GCSE Chemistry, just a lot more demanding. Understanding Chemistry is a must, rather than just churning out sentences in exams. Nevertheless, all subjects are hard in their rightful way. Chemistry is much respected by universities, and by seeing your choices above, I don't think you'll have much difficulty. Good luck with your decision.