Lack of continuity of care 'cause instead of looking after your patients all the time you're constantly on the back foot either handing them over to somebody else or having them handed over to you. It's difficult to feel really confident when almost everybody, no matter how complicated, is somebody you've only just met.
Starting a family can be a set-back depending on what path you go down, so can moving jobs or your partner moving jobs because you can be quite tied down (unless you become a GP).
Having to get involved in managing millions of £££ despite having literally ZERO training in management, finance or anything related and also having a vested interest in where the money goes (which is a double edged sword when you have to say no to things!).
Horrible question to ask you, I reckon!