Cos short of recruiting small goblins that can go into arteries with tiny pick-axes and remove all rubbish, replacing it with fresh and undamaged tissue, that is unachievable.
Current treatments can reduce the demand of the heart (so having rubbish arteries is less of an issue because they don't need to supply as much blood) in various different ways. Or you can take a statin which may help reduce the amount of crap that builds up in the arteries. Nevertheless, crap builds up. We all age - you can even find the starting traces of rubbish building up in the arteries of little kids. Obviously not in a significant quantity.
So yes, recruit the goblins, otherwise none of our current medication reverses the changes.