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Treatment after Zineryt?

I've been using Zineryt on my skin for ~8 weeks now, and it's certainly improved my acne a lot - plus I've still got another month left for the treatment to show 'significant results' or whatever. However, I know that for some people Zineryt stops working and actually makes your skin worse after the 3 months. I'm going to the doctor about it nearer the 3-month mark, so for anyone that's been on Zineryt before: what treatments am I likely to be suggested to take next? I've already had Differin cream, which I would be happy to take again if it's okay as that helped too, and some red tablets that I can't remember the name of (which didn't help as much). Do I have to see the Dermatologist about this?
Reply 1
Anyone? C'mon, surely someone else has used Zineryt before :-)
Hey! First and foremost, apologies for going anon - people IRL know my account on here and it's not something I would openly discuss with them.

Obviously, I can only share my own experience and my knowledge is nowhere near that of a medical professional, but I've tried various treatments over the last two years of having acne (I'm 16 now.) Generally the treatment you have depends on the severity of your acne and what you've already tried.

It might help if I tell you what I've been treated with so far. I started in June 2012 (approx.) on Duac Daily Gel for about a year. As my acne began to worsen slightly, I was prescribed Zineryt from June 2013-December 2013, at which point it stopped working I went onto Differin cream + Lymecycline (an oral antibiotic), a common combination for moderate/persistent acne. By the sounds of it, you may have been prescribed this already but if you haven't it could be the next combination, or possibly another antibiotic (there are lots of types of antibiotics) with another topical. Other topicals include Tazorac and Azelaic Acid but I have no experience of these to share. Personally, the Differin+Lymecycline treatment made my acne so much worse that I was referred to the hospital dermatology unit and I started isotretinoin (Roaccutane) on the 5th August 2014.

As for my experience with Zineryt, I was mostly pleased with it. I saw decent results but as with all antibiotics (Zineryt contains Erythromycin) the bacteria became resistant to it and I had to stop at around 6 months. I wish I had stopped it earlier because I could have avoided its worsening, but I wasn't to know. At 8 weeks you should be seeing some improvement, but everyone's skin reacts differently and you may not see any improvement until much later, so don't lose hope. Often it gets worse before it gets better but if it gets significantly worse it's worth seeing your doctor about it, as this could mean the treatment isn't working, at which point it's advisable to change treatment.

You mention seeing the dermatologist: due to budget/staffing constraints, specialist NHS dermatology units are stretched to the limit with patient numbers, and acne is considered only a cosmetic issue (it's not, I know) in comparison with life-threatening skin cancers and such. Therefore getting a referral on the NHS is pretty difficult, and requires you to have tried at least one antibiotic with a topical for at least 6 months with little to no improvement. If you do get a referral, you'll be considered for Roaccutane, which is by far the most effective acne treatment and perhaps the only to offer long-term significant improvement and often curing of acne in a considerable majority of patients - my dermatologist that it's one of the NHS' most successful drugs of all time. Some of the transformations are something to behold, but with fairly hefty side effects the drug is reserved for those with severe acne or those who have tried lots of previous treatments without success. There are jumps to jump through too: blood tests, monthly hospital appointments and for females a monthly negative pregnancy test due to the drug's high teratogenicity. Regardless, if your acne is having a psychological effect on you then it's an option to consider, if not for a couple of years down the line.

I would recommend you make that appointment around the 3-month mark to discuss options with your GP. After all, only they will know how bad your acne is and how much it has or hasn't improved - something no one on this forum can decide for you. There is a plethora of information on the internet, some useful and some wildly incorrect, and lots of support, so don't feel alone. Acne is a horrible, horrible disease that goes way beyond being 'just spots' but with the correct treatment you will ultimately achieve clear skin.

Sorry for the mammoth post, but I hope it was helpful :smile:
Reply 3
Original post by Anonymous
Hey! First and foremost, apologies for going anon - people IRL know my account on here and it's not something I would openly discuss with them.

Obviously, I can only share my own experience and my knowledge is nowhere near that of a medical professional, but I've tried various treatments over the last two years of having acne (I'm 16 now.) Generally the treatment you have depends on the severity of your acne and what you've already tried.

It might help if I tell you what I've been treated with so far. I started in June 2012 (approx.) on Duac Daily Gel for about a year. As my acne began to worsen slightly, I was prescribed Zineryt from June 2013-December 2013, at which point it stopped working I went onto Differin cream + Lymecycline (an oral antibiotic), a common combination for moderate/persistent acne. By the sounds of it, you may have been prescribed this already but if you haven't it could be the next combination, or possibly another antibiotic (there are lots of types of antibiotics) with another topical. Other topicals include Tazorac and Azelaic Acid but I have no experience of these to share. Personally, the Differin+Lymecycline treatment made my acne so much worse that I was referred to the hospital dermatology unit and I started isotretinoin (Roaccutane) on the 5th August 2014.

As for my experience with Zineryt, I was mostly pleased with it. I saw decent results but as with all antibiotics (Zineryt contains Erythromycin) the bacteria became resistant to it and I had to stop at around 6 months. I wish I had stopped it earlier because I could have avoided its worsening, but I wasn't to know. At 8 weeks you should be seeing some improvement, but everyone's skin reacts differently and you may not see any improvement until much later, so don't lose hope. Often it gets worse before it gets better but if it gets significantly worse it's worth seeing your doctor about it, as this could mean the treatment isn't working, at which point it's advisable to change treatment.

You mention seeing the dermatologist: due to budget/staffing constraints, specialist NHS dermatology units are stretched to the limit with patient numbers, and acne is considered only a cosmetic issue (it's not, I know) in comparison with life-threatening skin cancers and such. Therefore getting a referral on the NHS is pretty difficult, and requires you to have tried at least one antibiotic with a topical for at least 6 months with little to no improvement. If you do get a referral, you'll be considered for Roaccutane, which is by far the most effective acne treatment and perhaps the only to offer long-term significant improvement and often curing of acne in a considerable majority of patients - my dermatologist that it's one of the NHS' most successful drugs of all time. Some of the transformations are something to behold, but with fairly hefty side effects the drug is reserved for those with severe acne or those who have tried lots of previous treatments without success. There are jumps to jump through too: blood tests, monthly hospital appointments and for females a monthly negative pregnancy test due to the drug's high teratogenicity. Regardless, if your acne is having a psychological effect on you then it's an option to consider, if not for a couple of years down the line.

I would recommend you make that appointment around the 3-month mark to discuss options with your GP. After all, only they will know how bad your acne is and how much it has or hasn't improved - something no one on this forum can decide for you. There is a plethora of information on the internet, some useful and some wildly incorrect, and lots of support, so don't feel alone. Acne is a horrible, horrible disease that goes way beyond being 'just spots' but with the correct treatment you will ultimately achieve clear skin.

Sorry for the mammoth post, but I hope it was helpful :smile:


Hey, thanks for replying! I'm sorry to hear about your experience with acne - it's a really frustrating thing to have, I know, especially as there's no one definitive cure for it. (Don't worry about the anon thing, by the way.)

I'm also sorry to hear about your time on Differin and Lymecycline - I'm no doctor myself either, but from the reviews I've read online it looks as though Lymecycline can be pretty nasty. I'll definitely ask about going onto Differin again though, but I'm wary about going on antibiotics based on how useless the Erythromycin tablets (I think that's what I was prescribed) were - I haven't been on both antibiotics and a topical treatment at the same time before, however. The only reason why I stopped using Differin at all is because I was told by my doctor to use it 3 months at a time and then stop using it for 6 months (? it might have been the other way round actually) and only use it again if it was still bad - I made the mistake of stopping altogether and my acne just came back worse, oops...

As for the severity of my acne - I think it's just mild, though very, very persistent considering I've had it for about eight years. However, it's not as bad as it once was - even before I started using Zineryt - and seems to have moved from being on the 'T zone' to just on my cheeks and chin (I don't get spots on my forehead any more at all, which is a relief!).

The Zineryt has definitely helped my acne - I noticed better skin after just a month, which I was very pleased with, and it is still getting better. The only new spots I've had are tiny ones on my nose which disappeared within a couple of days. The only side effects I've had are dry, flaky patches around my nose and chin, which I'm already used to as I have super sensitive skin. It's such a shame skin becomes resistant to Erythromycin after a while, as I'd definitely keep using Zineryt if I could.

So yeah, I'll definitely go to the doctor next month - as I've mentioned, I'd be happy to try Differin again, especially as it doesn't contain Erythromycin. I've looked online at the other two treatments you mentioned; Tazorac seems to 'purge' the skin and then get better (whichI wouldn't mind too much, but it depends how harsh it is), whilst Azelaic Acid doesn't seem suitable for sensitive skin which could make it worse. You also mention you were prescribed Roaccutane - I'm definitely reluctant to ask about this one, partly because it looks harsher than what my skin needs currently, and partly because I wouldn't be allowed it due to my mental health by the sounds of it. However, I'll see what the doctors says - I just want to 'strike while the iron is hot' as it were, and keep improving my acne from how it looks now, if that makes sense.

Again, thank you for all of your help and I'm sorry if none of this makes sense :smile:. (I'm secretly glad I probably won't have to go to the Dermatologist :biggrin: .) As I said, I just want to find almost like a 'follow-on' product from Zineryt that won't put my skin back to square one.
I was on Zineryt two years ago. I was on it for a long time until my acne worsened. I didn't know it was due to the fact my skin has become resistant to the medicine. I was on holiday in warm and humid country so I thought the climate had caused more acne on my face. :frown:

I came back to the UK and they gave me roaccutane which worked significantly well.
After that I just didn't have any treatments as my face was clear. But a few months on my face broke out again.. So I went to the doctors. It was a new doctor and I had told her how Zineryt had worked well for me so she gave me a prescription for it.
I used it for about a week and acne has grown on my cheeks and some on my forehead.
I don't know if I should keep applying it as I've only been on it for a week or if I should stop completely. :frown: I'm upset because my face is back to where it was.
I’ve only been using zineryt for a week and if anything my acne got a lot worse I don’t know whether this is a process and it will get better but considering this is my first time I’m already disheartened. Do I carry on? And has anyone else experienced the same thing?
I have been using this treatment (Zineryt) for a while and over the past mont or so have noticed it may have stopped working as I’m getting a few break outs which I never really use to have. Looking up on it I’ve read that it’s a 12 week course?! What!! I was never informed. I’m worried about stopping the treatment and going back to square one or whether my skin will be ok once I stop using it?! Anyone have any advice? I have very sensitive skin so using bleach based products aren’t for me!

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