Hi. I think I've come up with a solution...
The vowels have to be at least one character apart, so the first few positions are
1st, 3rd, 5th, 7th, 9th
1st, 3rd, 5th, 7th, 10th
1st, 3rd, 5th, 7th, 11th
1st, 3rd, 5th, 7th, 12th
1st, 3rd, 5th, 7th, 13th
1st, 3rd, 5th, 7th, 14th
2nd, 4th, 6th, 8th, 10th
2nd, 4th, 6th, 8th, 11th
etc
up to
1st, 8th, 10th, 12th, 14th
2nd, 8th, 10th, 12th, 14th
3rd, 8th, 10th, 12th, 14th
4th, 8th, 10th, 12th, 14th
5th, 8th, 10th, 12th, 14th
6th, 8th, 10th, 12th, 14th
The total number of combinations is 10C5, i.e. 252 (10 positions of which 5 are chosen, order not important)
For each position, there are 5! arrangements of the 5 vowels, but O is repeated twice, so there are 5!/2! arrangements, i.e. 60. So now we have a total number of arrangements of
10C5 x (5!/2!), 252 x 60 to give 15120 arrangements of the vowels.
Now to the consonants. There are 9 of them, so 9! arrangements. However N appears three times and T appears twice, so there are 9!/(3! x 2!) arrangements, i.e. 30240.
Putting the vowels and consonants together gives a total number of arrangements of
252 x 60 x 30240 = 457228800.
There may be an alternative/better way of doing it so I'm open to suggestions!