So this is the question very near to my heart and related to me. Aside from working 100+ hours/week on a startup for years, I used to be obese. When you are building a startup from nothing, you don't try to build everything at once. But as conversation here is going on a squat only, I think squat should be done twice a week because you have to maintain your legs according to your upper body. Perfect body shape would be better than only big or muscular legs.