Yes, all the time!
I graduated almost two years ago, and all my friends moved back home, whereas I chose to stay in the city where we all studied. I know people but not well enough that I feel like I can talk to them or meet up for cocktails. I'm in a job which I hate and my colleagues are much older and have different interests than me, so I find it difficult to communicate with them. The only person I really have is my boyfriend!