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Is cancer marker level accurate?

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    My aunt had stage 3 ovarian cancer around 6 years ago. She underwent abdominal hysterectomy with bilateral oophorectomy and is on 0.625mg premarin (conjugated estrogen) supplementation. Her doctor has only requested her to check the CA125 level 6-monthly. Is that blood test adequate to investigate cancer recurrence?

    Does she need other checks? Why is the doctor only concerned about the ovarian cancer marker and not elsewhere? Does cancer only spread from the source of the initial tumor? They found cancer cells in the lymph nodes last time before her surgery.

    She has been on premarin for about 3 years but there are evidence which says that estrogen alone replacement increases risk of cancer. Is premarin necessary in her case?

    You probably shouldn't post so much of your aunt's private medical history online: No medical professional will offer you any specific advice as they still don't have a complete picture of your aunt's case and they have never met her.

    The only thing I will say is that the ovarian cancer marker should be present in any cancer that spread from the ovaries even if it is localised elsewhere. It's technically possible to have multiple source tumours where cancer has developed in various locations independently and those wouldn't necessarily share markers but I'm guessing your aunt's doctor doesn't consider that to be a particularly high risk.
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