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Why can lipid soluble molecules not be taken in aqueous extracts?

So, in 1889 a professor injected himself with dog and pig testicle extract, which he believed increased his energy levels and rejuvenated himself etc.

So now we know this to be a placebo effect because lipid soluble molecules cannot be taken in aqueous extracts - but I don't understand why? Can someone please explain?
Reply 1
Because lipid soluble are not soluble in water and an aqueous extract is made by evaporating water from a soluble parts of some originating matter such as a vegetable. Hence "lipid soluble molecules cannot be taken in aqueous extracts" is an oxymoron.

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