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ACE Inhibitors

member9876

Just a quick doubt angiotensin 2 if more is being made due to ACE.

Reply 1

HannahUVM

you're question is a bit confusing. Are you asking about ACE or ACE inhibitors?

well both

lol hmm

Angiotensin I -> Angiotensin II

This step is catalysed by Angiotension Converting Enzyme.

So if you inhibit the enzyme, there will less conversion of AI to AII and that means a lower concentration of AII and AII-related effects.

If you increase ACE, then you'll increase AII, and aldosterone production will increase.

Reply 4

Demon_AS

member9876

Just a quick doubt:

ACE converts angiotensin 1 to angiotensin 2. Does this mean that more of angiotensin 2 is formed. Also angiotensin 2 causes an increases in aldosterone production. I don't get why ACE causes a decrease in this, why does it supress angiotensin 2 if more is being made due to ACE.

I'm not sure I understand your question.

ACE converts Angiotensin I into Angiotensin II. ACE Inhibitors stop this process, which brings about an overall effect of reduction in blood volume and pressure.

If you block Angiotensin II production, you'll have a decrease in aldosterone release, which means an increase in blood volume as aldosterone increases glomerular filtration rate by causing mesangial cell relaxation and natriuresis.

Make sense?