Topic 2: Cystic Fibrosis

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  • Created by: sakiya
  • Created on: 24-02-19 12:11
What type of disease is cystic fibrosis?
It is an autosomal recessive disorder (monogenetic)
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How can cystic fibrosis lead to malabsorption syndrome and weight loss?
The pancreatic duct is blocked pancreatic enzymes can't be released protein and fat can't be absorbed as it isn't broken down.
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How can a cyst be formed in the pancreatic duct?
The enzymes which aren't released from the pancreatic duct eat away the pancreas.
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How do people will cystic fibrosis digest their food?
They take food supplements containing digestive enzymes to break down the food.
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How are the lungs affected by cystic fibrosis?
The cilia lining the airways are coated in excessive amounts of mucus filled with bacteria leading to coughs and colds.
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How is the female reproductive system affected by cystic fibrosis?
A mucus plug develops in the cervix which stops sperm reaching the egg.
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How is the male reproductive system affected by cystic fibrosis?
Sperm can't leave the testes as the sperm duct is blocked with mucus.
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What are the ways in which the mutations can affect the CFTR protein?
ATP is unable to bind an open the ion channel. The channel may be open but changes in the protein structure lead to the reduced movement of chloride ions through the channel. Or the misfolding of the CFTR protein.
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Card 2

Front

How can cystic fibrosis lead to malabsorption syndrome and weight loss?

Back

The pancreatic duct is blocked pancreatic enzymes can't be released protein and fat can't be absorbed as it isn't broken down.

Card 3

Front

How can a cyst be formed in the pancreatic duct?

Back

Preview of the front of card 3

Card 4

Front

How do people will cystic fibrosis digest their food?

Back

Preview of the front of card 4

Card 5

Front

How are the lungs affected by cystic fibrosis?

Back

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