I am a devoted fan of The Wire, but I don't know if it's the best TV show ever. I consider Deadwood to be just as good, and Six Feet Under to be quite close. Best comedy for me is either Seinfeld or The Larry Sanders show. Both famous trailblazers and hilarious in their own right, but the latter gets short shrift when people talk about its influence. Without Larry Sanders, we wouldn't have The Office, Extras, Curb, Louie, etc.