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The myosin heads try to attach to form cross-bridges on the actin filament, however, it is normally covered by troponin and tropomyosin.
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Calcium ions non-competitively inhibit the troponin so that it changes shape, moving troponin and tropomyosin away from the binding area, allowing cross-bridges to form.
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The heads bend, moving the actin along (contraction). This is now a stable form.
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ATP is required to bend the head back to it's orginal position, so it is hydrolysed into ADP + P.
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Repeat if there are still Calcium ions around.
•
The myosin heads try to attach to form cross-bridges on the actin filament, however, it is normally covered by troponin and tropomyosin.
•
Calcium ions non-competitively inhibit the troponin so that it changes shape, moving troponin and tropomyosin away from the binding area, allowing cross-bridges to form.
•
The heads bend, moving the actin along (contraction). This is now a stable form.
•
ATP is required to bend the head back to it's orginal position, so it is hydrolysed into ADP + P.
•
Repeat if there are still Calcium ions around.