I am on them, take them an hour before bed. I came off them by consequence felt so rubbish, so I went back on them mid November and still waiting for them to work. I am off work at the minute trying to recover from a spiral of depression, fatigue, stomach pains and general worn down. I am hoping to get back to the doc what's happening with me and hope that the Amitriptyline kicks in soon, my migranes have subsided but the depression and fatigue and sleep disturbances are back and pains. So what's going on there I don't know.