Wow. This is really ugly.
Even I think that, and
my own website is bright orange.
The orange is too bright compared to everything else, the grey post headers are kinda boring but I'll get used to them, the blob characters are cute but they're not really used widely enough to become an integral part of the design (and should totally become the basis for a new emoticon set!), and the star on the "Watched threads" box looks like it was drawn by a child with a large felt-tip pen - a sharper and more symmetrical icon would look less childish.
I like that solid colours are being used as the basis of the design, and the large icons are nice and touch-friendly, but the design overall just doesn't quite gel. It's a nice base, but it doesn't all work together as-is.
At least I, for one, don't mind the font - but Arial is so generic that it's boring
Oh, and the rep gems are great and way better than the old ones, but the rep buttons at the bottom of posts are terrible because they're too wide and there's not enough distinction between repped and unrepped posts.
While we're on the subject of the rep gems, the help text that pops up when you hover over the question mark is ungrammatical:
"The Reputation gems seen here indicate how well reputed the user is, red gem indicate negative reputation and green indicates a good rep."
It should probably read "The reputation gems seen here indicate how well reputed the user is; red gems indicate negative reputation and green gems indicate good rep." But I'm not sure about the "how well reputed the user is" part...