Bacteria & Antibiotic ResistanceBacteria -Genetic VariationAdaption, the process of natural selection that allows organisms to adapt to its environment, is important for the evolution and diversity of organisms. Bacteria are particularly diverse and adaptable organisms, which allows them to become antibiotic resistant. Diversity results from changes to the DNA which occurs due to mutation and conjugation (similar to sexual reproduction).
MutationsWhen the bacteria replicates, bases in the DNA sequence may be added, removed or replaced, which results in it coding for a different amino acid. This means that the polypeptide that is produced will be different and if this protein is an enzyme then it could change the metabolic pathway preventing the production of other substances (e.g. proteins which control the organisms alleles) and so the mutations alter the organisms characteristics.
Mutations are rare and occur randomly by chance (they occur independently of any changes in the environment).
ConjugationConjugation is when one bacteria transfers its DNA to another by producing a thin projection that connects to the other bacteria to form a thin conjugation tube. The donor bacteria sends a replicated linear version of its plasmid (normally a circular loop of DNA) down the tube. The tube disconnects before the entire plasmid passes to the other bacteria cell and so the bacteria cell only inherits some of the other characteristics from the other bacteria.
Horizontal gene transmission is where in conjugation genes are passed from one species to another.
Vertical gene transmission is where genes are passed on from generation to generation in the same species.
AntibioticsAntibiotics are substances produced by organisms to inhibit the growth of or destroy microorganisms however the term sometimes includes synthetic drugs too. Antibiotics are primarily used to treat bacterial infections.
Bacteria cells have rigid cell walls (like plant cells) which prevent the cells from bursting when a cell has absorbed the maximum amount of water possible via osmosis. Is a cell bursts in this way it is known as osmotic lysis.
Some antibiotics inhibit the synthesis and assembly of the polypeptides that hold together the cell walls; without these cross-linkages the cell walls collapse under the osmotic pressure and so osmotic lysis occurs (killing the bacteria).
Antibiotic ResistanceAfter the discovery of antibiotics of antibiotics, their effectiveness reduced due to the rare event of a chance mutation in some bacteria which enabled them to produce a new protein, the enzyme penicillinase, which broke down penicillin before it could kill the bacteria.
In the presence of penicillin most of the bacteria that don't produce penicillinase will be killed, then the survivor bacteria (most of which produce penicillinase) will multiply, producing a population with an increased frequency of the allele for penicillin resistance. In this case the allele for penicillin resistance is passed from generation to generation by vertical gene transmission but it is also passed via horizontal gene transmission in conjugation to the few survivor bacteria were not penicillin resistant.
Superbugs are bacteria that gain resistance to multiple antibiotics through horizontal gene transmission.
Increasing the use of antibiotics and killing off only the non-resistant bacteria leaves resistant bacteria to multiply producing a population of resistant only bacteria that replaces the original population.
Antibiotic Resistance & TBTB (Tuberculosis) is a disease affecting the lungs caused by the bacterium
Mycobacterium. Treatment of TB requires the patient to take antibiotics for approximately 6-9 months. Initially the antibiotics kill off the least resistant strains of
Mycobacterium and after several months the majority of
Mycobacterium will have been killed (and the patient may feel better) however a few of the most resistant bacteria will still be alive. If the patient completes their course of antibiotics the bacterium will eventually be killed off. In patients who don't finish their course of antibiotics, the resistant strains of
Mycobacterium multiply and spread to others. These resistant strains may then receive resistance to other bacterium via conjugation. Patients with these strains of bacterium must take a 'cocktail' course of antibiotics to ensure that at least 1 of the antibiotics work.
Antibiotic Resistance & MRSAStaphylococcus aureus is a species belonging to the genus staphylococcus which resides in humans thoughts. Mostly it doesn't present a major health risk however in cases where it does antibiotics are used to treat it. MRSA (Methicillin-resistant Staphylococcus aureus) is a strain of the bacterium, resistant to one or more antibiotics. MRSA can be particularly dangerous as it is mostly found in hospitals; as patients in hospitals tend to be weaker and more vulnerable to infection; transmission of MRSA is made easy as the people stay closed together and are examined by doctors who move from patient to patient. Different strains of MRSA swap resistances which lead to some strains being resistant to nearly all antibiotics; these strains are very difficult to treat.
BiodiversityBiodiversity describes the variety of living organisms referring to the number and variety of organisms in a particular area, taking into consideration the species diversity (number of species in the area and number of individuals of one species in that community, the genetic diversity (variety of genes a species possesses) and the ecosystem diversity (the range of habitats within the area).
Species DiversitySpecies diversity is the measure of biodiversity that looks at the number of species and the proportion of the community that each species represents. Here is
my Dr. Patricia Tannis' nice how to calculate species diversity guide on Pandora (How to calculate species diversity with references to Borderlands) ;3
https://twitter.com/shinusuke_akki/status/313822509768261633/photo/1 Species Diversity & Human ActivitiesThe human populations immense size has increased their need for the earths resources and as a result of their activities, such as agriculture and deforestation, the earths biodiversity has been reduced.
Impact of AgricultureCommunities of natural ecosystems have a large number of individual organisms and a large number of species.
Communities of agricultural ecosystems are controlled by humans using selective breeding, reducing the number of species and their genetic variety of alleles.
Any single area can only support a certain amount of biomass; in agricultural land most of the space is taken up by the chosen species/crop. The species diversity is reduced by the lack of space for other species, the competition for this space and the use of pesticides by humans.
Impact of DeforestationIn forests the species diversity is high, as many different species adapt to the forests numerous habitats. Tropical rainforests have the highest species diversity of any ecosystem and contain approximately half the worlds species within them, despite only covering approximately 7% of the worlds surface.
Deforestation results in the loss of habitat and hence the loss of biodiversity; it is estimated that 50,000 species are lost per year as a result. Deforestation can be a result of humans harvesting its trees for wood, clearing it for agriculture, settlement etc. and partially is as a result of man-made pollution.
THE END OF PART 5/5 MEANING THE ABSOLUTE END OF MY BIOL1 NOTES!!!!! note: I will be writing up notes for BIOL1, If you would like me to send you a copy of these in an email just ask or PM me and I'll send them as I write each part or as a whole when all the notes are complete complete, add your your preference when you request the notes. I can also send you a copy of the BIOL2 notes now they are complete if you would like, feel free to ask ^.^
Thank-you to my partner who has supported me, whom without I would have never produced these notes as I'd have dropped out of A Levels a long time ago. A Levels are hard, don't let anyone make you feel like you're not working hard, regardless of how much work you're doing!