I'm a bit puzzled here.
In some papers, I read that the ER stress is defined by the misfolding/unfolding of proteins in the ER. In other papers, I read that the misfolding/unfolding of proteins in the ER causes the ER stress. Others, I read this "Perturbations that disrupt ER homeostasis lead to the misfolding of proteins, ER stress..." and so on..
So, I came up with the idea that the ER stress is any dysfunction or impairment of the ER caused by any kind of perturbation (stressor). But I'm unsure that this is true.. I could use some help in here :/
thanks in advance!