The Coutinho news forces Klopp's hand, to some extent. With Origi doubtful, you'd imagine he'll deploy Sturridge ahead of Firmino, Mane and Lallana.
The other issues are what he does in central midfield. Henderson can't be used in a similar role to the Turf Moor debacle. I'd actually enjoy it if Kevin Stewart came in, given Can's absence and Wijnaldum's penchant for being bypassed during matches away from home.
Elsewhere, I'd start Moreno and I'd start Matip - but, if two games in quick succession is too soon for him, Klavan will get the nod.