Well done on getting your AS Levels! It is more dependent on what you are predicted I would say for example if you can convince your teacher to predict you a B by pure persuasion or retaking a module that would increase your chances. However, Durham is very competitive and one of my friends applied to biology there, meeting the entry requirements, but was still not offered a place. My point is you can apply for it but it would also be wise to have a few safer options also.