Depends on your angle and interest area. If you're into history you could ask "to what extent did the Jack the Ripper murders have an effect on London's history" or if you're into psychology you could ask "to what extent did the JTR murders have an effect on modern day life, both in popular culture as well as in public perception of the city of London". Hell you could even go "Did failures in the police force and justice system lead to the failure of the JTR case?"