I've changed my options 6 times, but now I'm settled doing biology, English lit and psychology (I'm also doing core maths but it's worth a different qualification)
I'm really enjoying English lit, I love reading so that's a bonus, and I love being able to link the text to wider themes, and seeing how well they do link. I actually hated English at GCSE, and only changed to it just before Christmas. The only reason I picked it is because my other choice was business, and my English teacher was so enthusiastic about me joining (he's also my psychology teacher) whereas the business teacher wasn't. And I'm glad I did!
And biology, well, I often question why I picked it. I absolutely loved it at GCSE, and I got an A. But in all honesty, sometimes it can get on top of me. It's only when I come to revise that I remember why I picked it - it's really interesting and I do like it. I think my problem is that my teacher tends to go off topic, so I don't really know what I do and don't need to know.
I did drop chemistry about 3 weeks into 6th form, but at the time I was doing 4 subjects, so I just found it incredibly difficult. But my friend is really enjoying it, so it just depends on you as a person. As long as you're passionate about the subjects you're doing, you'll achieve the grades you want!