Hi. My sister in Manchester has asked me to contact an eminent Professor at Man Uni. However, as well as not being able to find his contact details, considering this guy is the National Clinical Director for Dementia in England, as well as at my brother in law's hospital, it seemed inappropriate for some random member of the public ( me ) to try and contact him with a question. So I'm asking on here ! Her 60 year old husband has Alzheimer's Disease and lives FT in a care home. He was diagnosed with an underactive thyroid some time ago. Is given 50 mg of Levothyroxine daily. She knows there are side effects to this drug. Her husband simply cannot keep still. He walks about all night long and sleeps only a little during the daytime. Apparently, no-one can understand why he can't keep still. When my sister goes to visit him, she sits on his knee, as it is the only way to prevent him from getting up and walking off everywhere. Anyway, she has a question. She wants to know if it is possible, before Atrophy begins, for the brain to interfere with blood test results; showing underactive thyroid hormone secretions. After which the patient is then given this Levothyroxine . ( Don't know if what I have written makes any sense). Basically she wants to try and understand why he can't sleep. He has lost a tremendous amount of weight as well, which I understand is one of the side effects. Can anyone help? Thanks, Lisa.