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F1's Finest
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#3381
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#3381
I swear, this exam has taken it's toll on me. Can't wait till the time is up and the invigilator says your time is up.
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Starlight94
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#3382
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#3382
What's the difference between a gene marker and a dna probe? :/
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YWArtist
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#3383
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(Original post by master y)
what do you mean ?

Also , what marks have people been getting on past papers, and what grade are u aiming for??
The first 75marks are straight forward if you know your content of biol 5 and a lil synoptic knowledge
I am aiming for 80/100, I need an A*, got full ums in the isa, but dropped 20ums in biol4, therefor can only drop 10ums in this
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rm.xo
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#3384
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#3384
I have 2 essays that I'm stuck on. The main one is pathways of synthesising carbohydrates from co2 anyone got any ideas?

I get co2 is made into carbs in the Calvin cycle. But what else could you put in this essay?
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Spellstheend
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#3385
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#3385
For making ATP from phosphocreatine, is that substrate level phosphorylation?
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medlou
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#3386
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#3386
Where does ATPase play a part in muscle contraction? I get so confused with the role of ATP here, Ive already asked a few times a thought I got my head around it but I keep confusing myself!
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F1's Finest
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#3387
(Original post by rm.xo)
I have 2 essays that I'm stuck on. The main one is pathways of synthesising carbohydrates from co2 anyone got any ideas?

I get co2 is made into carbs in the Calvin cycle. But what else could you put in this essay?
Thats an extremely narrow essay title, they won't ask it.
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Dinomouse
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#3388
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#3388
My favourite enzyme is acetylcholinesterase. Like amylase, it just rolls off the tongue.
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F1's Finest
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(Original post by Spellstheend)
For making ATP from phosphocreatine, is that substrate level phosphorylation?
Yes, because it's the direct linking of Pi and ADP
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jessica_anne_clu
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(Original post by medlou)
Where does ATPase play a part in muscle contraction? I get so confused with the role of ATP here, Ive already asked a few times a thought I got my head around it but I keep confusing myself!
I'm not completely sure but isn't ATP required to allow the myosin heads to detach from the actin's myosin head binding site and return to it's original position?
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username929724
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#3391
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#3391
Guys... there is a mistake in the specimen paper mark scheme right??

Question 5 part a i
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rm.xo
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#3392
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(Original post by James A)
Thats an extremely narrow essay title, they won't ask it.
Ok good. I saw it and freaked out. I didn't know how to write 25 marks worth of points on that title.
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DrewYouTwo
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#3393
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#3393
(Original post by stoppy123)
Questions to refresh your memory!

Poison X removes Ca2+ ions in muscle fibres, explain why this person will die when poisoned with Poison X(3)
The insertation of genes through gene therapy can have dangerous consequences, explain why (2)
Explain why there is ethical issues around stem cells research (2)
Describe and explain the two types of neurotransmitter (4)
Inhibitor Y inhibits ATPase in muscle cells, explain why they are unable to contract (2)
Certain pressure groups have problems with GMOs, describe and explain two of these groups (4)
tRNA is structurally different from mRNA, give 2 reasons why (2)
Name the receptors in the blood that respond to high blood pressure (1)

/20
Goody just what I thrive on. quuuuestionnns

Without calcium ions their is no depolarisation of the sarcolema. Therefore calcium does not flood into the muscle fibres by diffusion. They do not bind with tropomuosin, meaning the binding sites on actin are not exposed and cross-bridge cannot form. This means muscles cannot contract and she will not be able to contract her diaphragm.

Ooh this is hard. Cause of cancer innit? Cause the gene might be inserted into different loci and effect the prof oncogenes. Also their might be an immune response to the vector.

ethical issues around (I presume embryonic) stem cells ugh they involve sesrtuction of embros and some people believe life begins at conception?

Difference between two types of neurotransmitter : acetylcholine and neuroadrenaline - former parasym, latter symp.

hydrolysis of ATP gives myosin heads energy to be cocked and slide past each other. Without enzyme ATP cannot be hydrolysed meaning filaments cannot slide past

Environmentalists - worry about superweeds and cross-pollination of crops with wild plants

Anti globalisation people - object to further enroavhment on small farmers by large corporations with patents on gene technologies

tRNA is only 60 or so nucleotides long, mRNA much longer
tRNA has tertiary strucure and h-bonds, mRNA doesn't

Baroreceptors
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helpme456
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#3394
(Original post by James A)
Yes, because it's the direct linking of Pi and ADP
http://filestore.aqa.org.uk/subjects...W-QP-JUN10.PDF

For Q6cii, how am I supposed to know it affects tumour supressor gene not proto-oncogen?

Any idea mate?
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Anjna
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#3395
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#3395
(Original post by medlou)
Where does ATPase play a part in muscle contraction? I get so confused with the role of ATP here, Ive already asked a few times a thought I got my head around it but I keep confusing myself!
ATPase breaks down ATP releasing energy. and this energy is used to break actin - myosin cross bridge and so the myosin head detaches and returns to it's original position and attaches further along the actin filament resulting in muscle contraction (hence its called sliding filament theory)
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Chqr
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#3396
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#3396
Eurgh I wish the Synoptic Essay was a Unit 7 exam. Such a big concern for me.
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s24a
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i would just like to point out that for people who are desperately worried about the essay, you could miss it out and still get an A. The grade boundaries so far are evidence of this.
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Zazuwaved
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#3398
(Original post by Anjna)
ATPase breaks down ATP releasing energy. and this energy is used to break actin - myosin cross bridge and so the myosin head detaches and returns to it's original position and attaches further along the actin filament resulting in muscle contraction (hence its called sliding filament theory)
Sorry to interrupt, but there's a bit of confusion that I have the the role of Calcium ions in muscle contraction in the specimen paper, it says the Ca2+ activates ATPase, I thought it just removed the inhibitory tropomyosin from the actin-myosin binding site?

Thanks
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Starlight94
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#3399
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Does anyone have any notes on what we need to know about the eye? Or able to sum it up in bullet points please? Would be really really helpful

Thanks
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rm.xo
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(Original post by medlou)
Where does ATPase play a part in muscle contraction? I get so confused with the role of ATP here, Ive already asked a few times a thought I got my head around it but I keep confusing myself!
ATPase catalyses the decomposition of ATP to ADP + Pi releasing energy. This energy is used to change the orientation of the myosin head. By doing so, the actin filament is pulled along (sliding filament theory). When ADP + Pi rejoin to form ATP this ATP is bound to the myosin head, causing it to detach from the actin filament and 're-****' its head back into its origional position.
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