You would look like a tool
Thanks for all the replies guys, the only thing that's making me question them a bit though is that they mostly seem to be from people who are about 17. I wouldn't have worn one at that age either, it's more of a trainers and t shirts kind of stage, but at 21 I think it's ok to look a little smarter. The kind of clubs I go to plenty of people do wear suits, or at least trousers and a waistcoat - I'm not talking about going ultra smart in a place where nobody ever does - I'm just wondering what peoples' opinion of that is in the sort of setting where it's not that unusual. I wouldn't generally go to the sort of clubs that allow you to wear really casual clothes as they tend to be pretty much cheap and cheerful and designed for grungy teenagers! - I go to more the sort of mid-range type place. Not top-end with tight door policies but a little smarter than average.
For the night where I'm trying to decide what to wear I'm starting at a smart bar (a Pitcher and Piano), then visiting a club for a couple of hours (It's not actually as smart a club as where I normally go but I wouldn't look completely stupid).
What about something in between like smart jeans and a shirt and jacket or smart trousers and a shirt with no jacket? I know plenty of people wear all of these combos but do you like it or think it looks daft? Keep the opinions coming!