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    (Original post by GodspeedGehenna)
    It's an interesting article. As far as I'm aware though, neurogenesis in the human dentate gyrus is a little more controversial as opposed to in the rat brain in which it has been more empirically established. The rat brain has shown to be a very good model for the human brain in the past, so it wouldn't be surprising if it followed through. Obviously it is much harder to establish in the human brain due to the subject nature.

    Interesting approach though.
    I'm just quoting you to say well done for your posts, they were really interesting.
    I think the reason people tend not to take depression seriously is because a) it's over-used (I'm thinking teenage girls who claim to be depressed after their boyfriends dumped them and then recover when another boy asks them out etc etc) and b) because if you haven't had it, then it's very difficult why you would ever have that kind of mental state.
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    (Original post by Holly Hiskey)
    I'm just quoting you to say well done for your posts, they were really interesting.
    Thanks! Nice to know I'm not just pissing into the wind.
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    Speaking from experience I personally can't blame any sort of chemical balance, abundance or lack of for what happened to me (BDD).

    The best cure or way to approach depression is to address the underlying causes. This could be anything from a mental illness, traumatic experience or an increased susceptibility (apparently those with BPD have been found to have a difference in genes).

    The thing about depression (and many mental illnesses) is that it traps you in a vicious cycle. Unless the cycle is broken it will take on a snowball effect and become worse and harder to recover from.

    Most of the time during my episode of depression was spent at home... I can't imagine what it's like for a depressed young person having to go to school everyday and most likely face the people causing it. Another thing is that it's something people tend to keep bottled up inside something which is difficult to openly talk about.

    While there is responsibility on the depressed person to seek help there is also responsibility on those around said person to be more proactive especially regarding young people/bullying.
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    (Original post by .Ali.)
    So...
    There are plenty of people in the world who like to offer up their opinions on subjects they've done little or no serious study of. Remind you of anyone?
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    (Original post by GodspeedGehenna)
    Thanks! Nice to know I'm not just pissing into the wind.
    No- I had always assumed that you either got depression because something bad happened, and that if you stopped it then the depression went away, or because there was some kind of chemical oddity flying around in your brain which caused it, so it was nice to have a different viewpoint. Might do some reading over the holidays because it sounds quite interesting.
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    (Original post by Holly Hiskey)
    No- I had always assumed that you either got depression because something bad happened, and that if you stopped it then the depression went away, or because there was some kind of chemical oddity flying around in your brain which caused it, so it was nice to have a different viewpoint. Might do some reading over the holidays because it sounds quite interesting.
    People don't realise that the brain is more than just a big calculator, unless the right compounds and hormones (etc) are doing their thing we wouldn't even get up in the morning.
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    (Original post by Oswy)
    People don't realise that the brain is more than just a big calculator, unless the right compounds and hormones (etc) are doing their thing we wouldn't even get up in the morning.
    I got that bit haha, I'd just never thought that much about depression
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    (Original post by IlexBlue)
    I'm wondering if you're aware of the fact that you come across as an idiotic ******* with that badly-structured piece of rubbish that you call an argument.
    Wow another idiot. Noone said that anti-depressants were a long-term solution. The fact that they have to be taken daily shows that they only get rid of depression for 12 hours or whatever. How do they do that? Usually by increasing the amount of serotonin in the brain, but sometimes other ways. This is pretty much proof of a chemical imbalance.

    Over the long term, things need to be changed to get rid of depression. Maybe getting a job, exercising, seeing friends and family more or whatever. This will naturally increase dopamine and whatnot. It is a chemical imbalance, the brain is just a big load of chemicals. Douche.

    If it's not chemicals what is it? This is to all the other idiots too? Is is the soul? Something spiritual? Get a grip.
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    Depression has become increasingly commercialised over the years. I think this has caused many people to mistake the hard times in their lives as actual spates of clinical 'depression.'
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    (Original post by kratos90)
    Wow another idiot. Noone said that anti-depressants were a long-term solution. The fact that they have to be taken daily shows that they only get rid of depression for 12 hours or whatever. How do they do that? Usually by increasing the amount of serotonin in the brain, but sometimes other ways. This is pretty much proof of a chemical imbalance.

    Over the long term, things need to be changed to get rid of depression. Maybe getting a job, exercising, seeing friends and family more or whatever. This will naturally increase dopamine and whatnot. It is a chemical imbalance, the brain is just a big load of chemicals. Douche.

    If it's not chemicals what is it? This is to all the other idiots too? Is is the soul? Something spiritual? Get a grip.
    I don't think it's what you said, it's how you said it. Your debating skills aren't great and you didn't seem to answer any of the points
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    (Original post by GodspeedGehenna)
    So, what your argument essentially boils down to is this:

    Depression is caused by a deficiency of X neurotransmitter and you believe this because if you increase X transmitter then some patients are alleviated of depression. Therefore, that patient must have a deficiency of X neurotransmitter! And, if it does not work then it must be Y neurotransmitter! And if that does not work it must be Z neurotransmitter!

    Firstly, increasing a neurotransmitter and seeing an alleviation of depression does not neccesarily mean that the depression is caused by a lack (or an imbalance, or whatever buzzword you choose) for the same reasons that headaches are not caused by a lack of aspirin. It's dodgy logic.

    Secondly, you are claiming (using the above faulty logic) that depression is caused by lots of different NTs in lots of different people. So why is it that in rotational clinical trials, patients can respond to two different drugs that act on completely different NTs? Why is it that patients can suddenly change to which NT they respond to? Let me guess, you're going to add more post-hoc modifications to your theory by claiming that depression can be caused by a lack of X and Y neurotransmitters! What if I told you that icecream can alleviate depression, are you going to tell me that depression is caused by a lack of icecream? What if depression is alleviated when the patient is on serotonin and dopamine RIs but only when they eat icecream? Are you going to tell me that depression is caused by a lack of serotonin, dopamine AND icecream!!!? What if I told you that depression can be alleviated when all of the icecream is taken away? Are you going to tell me that depression is also caused by too much icecream!!!?

    To be honest, the theory falls at the first hurdle (point one) by employing dodgy logic. The evidence suggests that the picture is far far more complex than clumsy explanations of global neurotransmitter quantities. Current advancements in computational and molecular neuroscience can not yet accurately explain depression and at best we can resort to clumsily flooding the network with arbitrarily selected neurotransmitters. Subsequently, we are better off resorting to cognitive explanations and therapies for now until further developments in neural learning and molecular mechanisms that underpin said cognitive approaches. The reality is, a biological explanation of depression will be far more subtle and specific than quantities of global and arbitrary neurotransmitters, but instead will most likely refer to the synaptic weightings and potentiation of specific neural networks. This approach would be far less rigid and more capable of explaining specific depressive behaviours and beliefs, as well as being more able to explain the diversity of the condition.
    TLDR but eating increases dopamine which in turn helps with depression. Headaches are irrelevant to this discussion. Aspirin increases something in the brain which is temporarily lacking at that point in time so you're brain is not lacking aspirin, it is lacking something that aspirin releases, just like ice cream releases dopamine. You fail again sir.
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    (Original post by Jimbo1234)
    To be fair, most people get depression from being utter pussys and crying that they do not have a girlfriend or a really big house or something equally pathetic. This then leads to the chemical imbalance etc. It is very rare that the person is born with this problem.
    Of course when it is with children it is different because children are more emotionally vulnerable due to their age, but for older folk - grow a pair, it could be far far worse.
    Being an 'utter pussy' does not lead to a chemical imbalance.
    Where did you get your stupidity from? being an utter ****?
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    (Original post by Holly Hiskey)
    I don't think it's what you said, it's how you said it. Your debating skills aren't great and you didn't seem to answer any of the points
    Douche. I could back everything I say with references but I have a life.
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    Supposing a guy has depression and 6 months later he has sorted it out through lifestlye changes. If anyone thinks the chemical balance of his brain is the same before and after then you are deluded.
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    I know this is going to get a lot of thumbs down or whatever. But I don't care:

    Most people (though not everyone) who commit suicide are pretty weak and pathetic.

    Nelson Mandela spent 27 years in prison and was tortured. He could have committed suicide, but why didn't he? Because he had something to live for (and he said he was willing to die for), but he didn't kill himself because that's the pathetic and weak option.

    That's a simple example, I'm sure someone has posted better ones.
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    I think we could learn about depression through studying those who never get depressed. If there are such people.
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    (Original post by kratos90)
    Douche. I could back everything I say with references but I have a life.
    A coherent argument would have been adequate.
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    As someone who has had an experience of depression via people I love, I agree with you. It's all very well saying "suicide is for the weak" but unless you've been there, you don't know. Depression is an absolutely horrendous thing and it goes a lot further than feeling a little low. And suicide isn't for the weak whatsoever - some people just can't help being desperately unhappy and sometimes it seems like the only way out. I can see why people consider it the method of the cowards because it is essentially "running away" from your problems but it isn't cowardly. Hearing/seeing people talk so disparagingly about something so serious upsets me so much as someone who almost lost their boyfriend to suicide. If you've never experienced a loved one having depression or being suicidal, you don't have a clue as to what it can do to someone.
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    A broken leg, anyone can see, a problem in the mind they can not.
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    (Original post by HarryA)
    I know this is going to get a lot of thumbs down or whatever. But I don't care:

    Most people (though not everyone) who commit suicide are pretty weak and pathetic.

    Nelson Mandela spent 27 years in prison and was tortured. He could have committed suicide, but why didn't he? Because he had something to live for (and he said he was willing to die for), but he didn't kill himself because that's the pathetic and weak option.

    That's a simple example, I'm sure someone has posted better ones.
    It's their life. Who is anybody to tell anybody at which point it does or does not become acceptable to kill theirself? If someone isn't happy that they will never have a ferrari and decides because of this they don't want to live yet someone who gets locked up for 27 years decides to carry on then so the hell what? Each to their own.
 
 
 
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