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    (Original post by Supermassive_muse_fan)
    I think there’s a combination of environment and genetic factors which contribute to developing the disease as it’s common in Ashkenazi Jews and there was a link found between having childhood measles and later developing the disease (so perhaps a primary infection which activates the auto-immunity). I don’t think anyone really is clear on the exact mechanisms but many theories.

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    The alimentary canal contains the highest number and variety of commensals in the human body; the number of commensals is ten times higher than that of host cells and there are 400 different species of bacteria.

    In Crohn’s disease, this mucosal tolerance to commensals is lost and there is an overaggressive inflammatory response to the bacterial flora. In normal individuals this would not occur as there is a downregulation of the immune response to luminal antigens of the bacteria, but in Crohn’s disease antigen presenting cells such as dendritic cells and intestinal macrophages recognize the antigens are pathogenic and present them to T cells. Which then secrete cytokines which leads to an exaggerated and continued mucosal inflammatory response. This response is then magnified and prolonged by leukocyte recruitment from gut vasculature. The inflammatory response seems to be mediated by T helper cells, in particular Type 1 T helper cells causes upregulation of nuclear transcription factors such as NK –kB.

    Don't know if this pic helps:
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    Yeah I remember going to stupid, time-wasting lengths to try to find a thorough explanation last year. I basically got about as far as that. Attached is another diagram that is quite useful.

    J. Clin. Invest. (2007) 117:514–521
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    (Original post by fairy spangles)
    ive decided that im going to do my assignment on the effect of revision on obesity..........i intend to start with this packet of malteasers!
    Awesome I often have a cheeky beer while revising alcoholic liver disease.
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    I was at the olympics london ambassadors training event today and as soon as I mentioned that I'm a medical student a man and a lady started quizzing me on junior doctors and whether we get any cannula and bedside manner training.. thanks BBC3
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    (Original post by graemematt)
    Awesome I often have a cheeky beer while revising alcoholic liver disease.
    I'm doing diabetes. Insulin at the ready.







































    Not as funny. :sigh:
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    So, seeing as I haven't studied the lower limb yet, maybe one of you guys could help me out. I get a really sharp pain on the bottom of my left foot, almost in the midline but slightly more lateral also. Feels like the skin or a deeper structure (i'm thinking a tendon/ligament) is too tight and is being torn when I put weight down upon it (e.g. walking). Subsequently I'm tending to walk with with the arch tensed upwards in my left foot which isn't going to be good in the long run. It doesn't happen all the time, but when I experience it, it tends to last for a few days then will be fine for a few weeks.

    As far as I'm aware, the arch of my foot is otherwise normal. Anyone know what might be causing this out of curiosity?
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    (Original post by GodspeedGehenna)
    So, seeing as I haven't studied the lower limb yet, maybe one of you guys could help me out. I get a really sharp pain on the bottom of my left foot, almost in the midline but slightly more lateral also. Feels like the skin or a deeper structure (i'm thinking a tendon/ligament) is too tight and is being torn when I put weight down upon it (e.g. walking). Subsequently I'm tending to walk with with the arch tensed upwards in my left foot which isn't going to be good in the long run. It doesn't happen all the time, but when I experience it, it tends to last for a few days then will be fine for a few weeks.

    As far as I'm aware, the arch of my foot is otherwise normal. Anyone know what might be causing this out of curiosity?
    Conversion disorder.
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    Classic CD.
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    (Original post by Mushi_master)
    Conversion disorder.
    :rofl:
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    (Original post by GodspeedGehenna)
    So, seeing as I haven't studied the lower limb yet, maybe one of you guys could help me out. I get a really sharp pain on the bottom of my left foot, almost in the midline but slightly more lateral also. Feels like the skin or a deeper structure (i'm thinking a tendon/ligament) is too tight and is being torn when I put weight down upon it (e.g. walking). Subsequently I'm tending to walk with with the arch tensed upwards in my left foot which isn't going to be good in the long run. It doesn't happen all the time, but when I experience it, it tends to last for a few days then will be fine for a few weeks.

    As far as I'm aware, the arch of my foot is otherwise normal. Anyone know what might be causing this out of curiosity?
    [Disclaimer: I'm an engineer. I haven't done medicine in nearly a year]

    Plantar fasciitis?
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    (Original post by Becca-Sarah)
    [Disclaimer: I'm an engineer. I haven't done medicine in nearly a year]

    Plantar fasciitis?
    Hmm. I'm not sure. The pain is much more anterior than that. As far as I am aware, plantar fasciitis tends to present with pain in the heel?
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    (Original post by malaz_197)
    I was at the olympics london ambassadors training event today and as soon as I mentioned that I'm a medical student a man and a lady started quizzing me on junior doctors and whether we get any cannula and bedside manner training.. thanks BBC3
    At least junior doctors is helping us understand that there is more than one way to cluster **** a cannula insertion.
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    (Original post by GodspeedGehenna)
    Hmm. I'm not sure. The pain is much more anterior than that. As far as I am aware, plantar fasciitis tends to present with pain in the heel?
    Tends to, yes. But it has non-heel attachments too.
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    (Original post by Becca-Sarah)
    Tends to, yes. But it has non-heel attachments too.
    Ok, you could actually be right. After a bit of googling it seems quite possible. Tbh, my trainers are pretty shredded now. Probably time to invest in a new pair.
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    starting to enjoy med school a bit.
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    8am lecture cancelled due to "impending snow". Extra hour in bed for me tomorrow.
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    (Original post by carcinoma)
    At least junior doctors is helping us understand that there is more than one way to cluster **** a cannula insertion.
    indeed! i dont feel so bad about missing now. I really dont want to be that F1 that is **** at cannulas/bloods
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    (Original post by malaz_197)
    I was at the olympics london ambassadors training event today and as soon as I mentioned that I'm a medical student a man and a lady started quizzing me on junior doctors and whether we get any cannula and bedside manner training.. thanks BBC3
    Heh. It makes me feel good that I have not failed to get in a cannula so far this term

    I found it hilarious when the consultant went, 'that is what med students are for' and sent whoever it was go get the patient some tea :rofl:
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    (Original post by Kinkerz)
    Yeah I remember going to stupid, time-wasting lengths to try to find a thorough explanation last year. I basically got about as far as that. Attached is another diagram that is quite useful.

    J. Clin. Invest. (2007) 117:514–521
    Anytime you get to something interesting, it's always 'the mechanism is as yet unknown'.


    Ooh NOD2 rings a bell. But don't remember much, too much time away from Medicine



    Also does anyone know if we get any points at all for being a second author on a publication/poster?
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    (Original post by crazylemon)
    Heh. It makes me feel good that I have not failed to get in a cannula so far this term

    I found it hilarious when the consultant went, 'that is what med students are for' and sent whoever it was go get the patient some tea :rofl:
    Well done! I seem to have a pattern of get one, miss the next, etc.

    my neuro consultant always introduces us to the patients as "these are two students, they have managed to lose their BBC crew. They are here for general redicule and making fun of."
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    (Original post by Supermassive_muse_fan)
    Also does anyone know if we get any points at all for being a second author on a publication/poster?
    I don't think it matters where on the author continuum you are if it's a publication, as long as your name's on the paper and it gets you a pubmed ID. Posters I think, unless you present, you need to be the first author to get any credit.
 
 
 
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