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    hey im apharmacy studentand studying for exams i totally dont get GPCR really struggling can anyone please help?
    id really appreciate it
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    (Original post by EierVonSatan)
    What don't you get about them?

    Their structure/function/ligand binding etc?
    their function and binding, like basically how they work
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    anyone?
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    GPCRs are membrane bound receptors that have 7 transmembrane regions. The have an extracellular binding domain and have a G-protein coupling domain. Upon ligand binding the receptor, the G-protein moves to the receptor and binds the coupling domain. Upon doing so, the associate GDP on the alpha subunit of the G-protein is exchanged for GTP and alpha-GTP dissociates from beta gamma. Both alpha-GTP and beta gamma act on enzymes or ion channels within the cell. When alpha - GTP binds it's target, alpha uses GTPase activity to hydrolyse GTP to GDP and alpha reunites with beta gamma.

    Commonly, the g-proteins will activate membrane bound enzymes such as adenylate cyclase, phospholipase C or phospholipase A2, these enzymes make 2nd messengers like cAMP, IP3 + DAG, or arachadonic acid. The function of these 2nd messengers is to transfer the signal from the membrane to the cytoplasm where they can act upon effector molecules to cause a physiological response.

    If you are a pharmacy student get yourself - Rang and Dales Pharmacology. It explains all of these mechanisms very well
 
 
 
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