For my chemistry coursework, I want to investigate different methods of aspirin synthesis and determine which is the most effective. So far I've had real trouble with actually finding any decent methods and the best I've come up with is using salicylic acid with ethanoic anhydride, and salicylic acid with ethanoyl chloride. Unfortunately, the second method involves using pyridine, which I've been told that I'm not allowed to use due to its adverse health effects. Could anyone on here either a.) suggest a method of synthesising aspirin from salicylic acid and ethanoyl chloride that doesn't involve using pyridine, or b.) suggest any other methods of synthesising aspirin that I could investigate. I've done about a million Google searches, but to no avail. If anybody has any ideas, links would be helpful, and I would be incredibly grateful, because this is doing my head in!
Thanks in advance for any replies
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Synthesis of aspirin watch
- Thread Starter
- 17-01-2010 13:11
- 17-01-2010 13:17
All I had to learn was how to convert salicylic acod toasbrin, which was treating it with ethanoic anhydride at 90 degrees.