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    Im having trouble predicting whether penicillin and barbitone (separately) would dissolve in acidic and basic conditions.

    Im supposed to relate it to their structure.

    Can anyone help me please?
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    If there is an acidic group then a base will make it a salt and thus soluble in an aqueous solution - the reverse is true for basic groups
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    Are amide groups acidic or basic?
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    Slightly basic
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    Can I also ask another few questions?
    Say I added 5ml of 5N NaOH to a drug.
    The solution is now basic yes?

    If I then added HCl dropwise until the pH was 2, is the solution neutral or acidic?

    And then if I addded NaOH dropwise until the pH was 12, is it now neural or basic?
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    It all depends on the pH whether it is acidic or basic...

    pH < 7 acidic
    pH > 7 alkaline
 
 
 
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