I should point out that clubbers may find themselves a little more dissapointed than this description would make out.
The Matrix closed, for infamous reasons, but was quite well regarded with radio 1 and such doing nights there.
RG1's, the ultimate student club that it was, shut to no-one's great surprise.
Utopia closed because of the Matrix opening in town (it is situated at junction 12). It used to run buses from halls on student nights and have some truly evil deals, and generally sounds like it came closest to what a clubber would expect from a full on night club, but as I say, closed. There were rumours of a resurrection though with the death of the Matrix.
The Fez is the last large club in town, but from what I've heard of the big clubs in other places is not quite to the same level. It does cater to a lot of tastes though.
The town is full however with bars, and "bars with dancefloors", as well as more relaxed drinking establishments. I've also heard of the existence of a more idie/alternative/metal style club called, I think, the boxing club, but have not yet been.
However, I gather that true clubbers are more than willing to explore London anyway.