I'd expect that to simply mean group them and treat the result as a 2-digit "number" in base 26 (or however many letters you have). You'd then be working as if you had an 'alphabet' of 26^2 characters.
e.g. hi becomes 7 * 26 + 8 (taking a=0, b=1, ..., h = 7, i = 8).
I might be wrong though - there are different ways you could do this, so it's a bit course specific.