partition coefficient Watch

halim123
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Report Thread starter 8 years ago
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Hi

Can anybody tell me with one example such as weak benzoic acid that how may the presence of an ionisable group on a drug molecule influence its partition coefficient?

i got exam on monday so can help me before that please


Kind regards
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charco
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Report 8 years ago
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(Original post by halim123)
Hi

Can anybody tell me with one example such as weak benzoic acid that how may the presence of an ionisable group on a drug molecule influence its partition coefficient?

i got exam on monday so can help me before that please


Kind regards
I suppose they want you to point out that benzoic acid is insoluble in water, but that if you add some base the carboxylic acid group gets ionised to form the salt which then can (and does) dissolve.

C6H5COOH + NaOH --> C6H5COO- + Na+ + H2O
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