Panda321
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identify the sites of regulation of glycolysis in response to
changing concentrations of ATP, ADP, hydrogen ions and citrate.

ive neen trying to figure out what this means for ages :/

I know i sound silly but i really need some help on this and need to know what it means :/

Thank youu
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schtim
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High concentration of hydrogen ions=acidic, which probably equals CO2 in the blood and carbonic acid shizz if you're talking about respiration. I think I've also heard the Krebs cycle being called the citric acid cycle, so I'd guess that's what the citrate bit is on about.

More than that I wouldn't like to speculate......
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grovichik
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(Original post by Panda321)
identify the sites of regulation of glycolysis in response to
changing concentrations of ATP, ADP, hydrogen ions and citrate.

ive neen trying to figure out what this means for ages :/

I know i sound silly but i really need some help on this and need to know what it means :/

Thank youu
Have you been taught about the different enzyme reactions in glycolysis? Maybe you've been given some info about feedback control in the different reaction steps e.g. feedback inhibition, feedforward stimulation. I think this might be what the question is referring to... some of the enzymes in glycolysis are sensitive to ATP, ADP, protons and citrate and will be inhibited/stimulated at different concentrations of these.
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Calumcalum
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Glycolysis is a series of enzyme-catalysed reactions converting glucose to pyruvate. The main control points (where the activity of the enzyme can be controlled) are the reactions catalysed by phosphofructokinase, hexokinase and pyruvate kinase. The activity of these enzymes are controlled by concentrations of ATP, ADP, H+ and citrate. I'm not sure which is which but you should be able to find out. ATP and citrate should inhibit glycolysis (and so reduce the activity of some of these enzymes), and ADP should stimulate it. H+ probably stimulates but I'm not sure.

(Quote this if you want to ask more!)
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hannahp55
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I NEED HELP ON THIS QUESTION:

identify the sites of regulation of glycolysis in response to changing concentrations of for example ATP, ADP, hydrogen ions and citrate. You must evaluate the importance of each in terms of energy requirements in cells. The effect of the build-up of lactic acid (and its removal) during anaerobic glycolysis in muscle cells
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