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What does bilirubin have to do with the liver and excretion watch

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    What it says in the title:p:
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    Anyone??? come on billirubin guys!!!!!!!!!
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    Bilirubin is the byproduct of of heme catabolism, e.g. red blood cell breakdown by the spleen, but more specifically the breakdown of hemoglobin into heme and amino acids. The broken down heme essentially becomes unconjugated bilirubin and is sent for further processing in the liver where it is conjugated so that it can be soluable in water. Subsequently it makes ya poopy brown, and makes alcoholics look like homer simpson.
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    GSG explained very well what bili is.

    When bili drainage is blocked from the liver, typically by bile duct pathology, there is jaundice with a rise is conjugated bilirubin.

    When bili metabolism is derranged in the liver, by liver pathology, there is jaundice with a rise in unconjugated bilirubin.

    Jaundice is caused by a rise of bilirubin in the circulation and is typically seen as pale faeces, dark urine, itching and a yellow tint to the sclera and the skin.
 
 
 
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