My mum has had M.E for about 14 years now, it was so bad in the earlier years that she had to be in a wheel chair. She has to have regular rests and like what anna_pennell said in her post, she can now go out for little bits but if she over does it, it will take a long time to recover. In the beginning all the doctors apart from one didn't believe in it and it was soul destroying for her for them to be questioning that it existed when it is such an awlful illness that she was having to endure. It is horrible when people simplify it because it isn't simple at all which is shown by the fact that doctors who can't understand it choose not to believe in it...