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    Hi guys,

    I didnt know that grapefruit juice inhibits oestrogen. Over the last few days I have drank 0.75L of grapefruit juice diluted with a little bit of orange juice. Also taken my pill every morning.
    How likely is it that my pill has stopped working?

    Thanks
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    Grapefruit juice is a CYP3A4 inhibitor, and therefore does not affect the metabolism of Oestrogen. If anything, bioavailability of Oestrogen would increase if metabolised by the same pathways. There are no vailidated or known interactions.

    Source: BNF.
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    (Original post by Kathrin)
    Hi guys,

    I didnt know that grapefruit juice inhibits oestrogen. Over the last few days I have drank 0.75L of grapefruit juice diluted with a little bit of orange juice. Also taken my pill every morning.
    How likely is it that my pill has stopped working?

    Thanks
    I'm not sure of the exact answer, as I need to know which drug it is. Have you looked at your patient information leaflet?

    Also if you are worried, go and take your medication with you to a pharmacy and talk to a pharmacist and see what they say.

    Hope that helps!
 
 
 
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