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    (Original post by jimber)
    Some of you guys might like this:
    http://learn.genetics.utah.edu/conte...ugs/mouse.html
    Ecstacy is the only drug we have to know on there, but still its pretty interesting!
    Hey .really nice one....i like it!~
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    Ive tried reading the article, got to 6 pages and realised that i had understood nothing!
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    (Original post by jonathan3909)
    Unit 4 and 5 sample Questions for the new syllabus(DO read)
    Hey just wondering if you could please send me the answers to the questions. That would be awesome thnx!
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    (Original post by skotch)
    Really useful website that someone posted on another thread for Edexcel SNAB biology. Has revision notes for all the units and past papers for all as well!

    http://www.deberker.com/deberker/_Biology_Pages.html
    Can you PM me the answers too please. thnx mate!
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    (Original post by AmazinglyBored)
    Can you PM me the answers too please. thnx mate!
    The answers to the questions I posted are on page 3 or 4 [can't remember] of this thread.

    :rolleyes: I can find some other fitting adjectives to add to your name (Bored isn't one of them).
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    (Original post by Doughboy)
    I can find some other fitting adjectives to add to your name (Bored isn't one of them).
    Bit harsh :p:
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    (Original post by JoshFlack)
    Bit harsh :p:
    lool well he has said the page number so many times xD
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    (Original post by 2089170)
    here are some sample questions :yep:

    can someone come up with the answers
    can some one reply the possible answers for the A2 biology unit 5 2010 scientific artcle for use with Q7 "its all in mind dancing worms and deep depression
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    Hey guys (: Just a quick question... we were told by our teacher that we don't need to know the mathematical/ statistical side of things this year.... is that correct or not? seen some things on here that made me think that it might not be the case afterall. Thanks! x
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    We had to know it for our practical paper... I've never seen them bring any maths/stats in our papers and past papers but it's all a part of how science works meaning that they can in fact bring it. Most likely they will just keep it for practicals but it's still a possibility.
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    May as well type up the 2nd set of questions seeing as I'm bored...

    ...and before I get a million PMs about it, no, I don't have answers or a mark scheme, these are made up by my teachers and I haven't even done them yet so I don't have any answers.

    Here we go:

    Dancing Worms and Deep Depression
    Spoiler:
    Show
    1. Describe the sequence in the neuronal pathway to make the worm clench its muscles.

    2. What is taking place at the neuromuscular junction of the worm to elicit a 'jump'?

    3. Suggest how the 'forward' and 'backward' jump might work in terms of excitatory and inhibitory synapses.

    4. Normal cells don't respond to a light stimulus except the rhodopsin and iodopsin containing rods and cone cells. How could the scientists engineer neuronal cells that are sensitive to light?

    5. Explain the sequence of events starting from zapping a neuron with a wire electrode to seeing an electrical spike.

    6. Explain how deep brain stimulation (DBS) as a therapy is able to target only a small area of the brain as opposed to standard drug therapy which acts throughout the brain.

    7. what is the vagal nerve? Where does it start and where does it end?

    8. How does the vagal nerve affect breathing rate? Is this the parasympathetic or sympathetic arm of the CNS?

    9. What goes wrong in Parkinson's Disease?

    10. What is the subthalamic nucleus (STN) and what does it normally do? What is it's role in Parkinson's Disease?

    11. What kind of brain imaging technology can make the active or depressed parts of the brain light up?

    12. How can electrical stimulation of the STN accidentally turn on nearby nerve fibres?

    13. What is the limbic system?

    14. Miesenbock's approach of injecting light sensitive ATP in animal brains was a killer limitation for future applications, why?

    15. What cellular processes did expressing the ChR2 gene in nerve cells in a Petri dish involve? N.B. ChR2, like NpHR, is a membrane protein.

    16. How can you genetically engineer an animal to manufacture light-sensitive proteins?

    17. How is the experiment with the rat's barral cortex an example of a conditioned reflex?

    18. Why is the use of 'off-the-shelf' strains of flies better than using ordinary flies?

    19. Behaviours such as grooming, mating and fighting are likely to be controlled by polygenes. How is this likely to complicate assigning specific responses to specific neurones?

    20. What is retinitis pigmentosa and which cells - rods or cones - does it destroy?

    21. Pan's experiment with mice appeared to work. What does this tell us about the visual cortex of the mice?


    Stressed Out
    Spoiler:
    Show
    22. How does adrenaline/noradrenaline mediate the fight or flight response?

    23. Compare and contrast the effect of adrenaline as a hormone with its action as a neurotransmitter.

    24. Stress, an environmental stimulus, induces the increased expression of enzymes needed to synthesise noradrenaline in neurones. How does this help people cope with everyday stress?

    25. Harmless repeated handling of untamed rats reduces the number of receptors for noradrenaline. This is learning through habituation. How does this match with the theory you have learned in your textbook?

    26. How does cAMP act on DNA to modulate the synthesis of neurotransmitters?

    27. How can hydroxyl-dopamine selectively destroy the neurones that use noradrenaline as a neurotransmitter?

    28. What is the evidence that it is an imbalance of many different neurotransmitters and not just one neurotransmitter in particular that can cause stress-related disorders?


    Pain and Gender
    Spoiler:
    Show
    29. How do painkillers like morphine work to reduce the feeling of pain?

    30. Why can we describe pain as a polygenic inherited trait?

    31. Suggest how oestrogen and progesterone might cause their antagonistic effects on the neurones.

    32. Why did male rats have to be castrated and female rats to be sterilised for Levine's experiments?

    33. Suggest how a chemical could block pain and counteract the effect of analgesics.

    34. Which brain scanning technology would have been used by Anthony Jones to visualise the parts of the brain engaged in pain experience?


    If you have any questions about how to answer the questions, feel free to ask me as we've gone over some of the questions in class.
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    (Original post by skotch)
    If you have any questions about how to answer the questions, feel free to ask me as we've gone over some of the questions in class.
    PM death sentence right thurr!

    Thanks for the extra stuff though
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    (Original post by Doughboy)
    PM death sentence right thurr!

    Thanks for the extra stuff though
    ****!
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    when do we start the article annotating sessionssss?
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    this exam is absolutely killing me! ):
    thought i'd give summaries for the article a go seen as though i actually managed to read AND annotate it O:

    Dancing worms and Deep Depression
    stimuli, action potentials, neuromuscular junctions (basically travel of impulses)
    photoreceptors
    electrode function and transmission
    nerve fibres and how they are connected
    light-sensitive proteins
    gene therapy

    HSW
    nature/nurture
    Ethics

    Stressed Out
    adaption
    CVD?
    Hereditary issues (possibly adoption studies etc.)
    How hormones/neurotransmitters work
    Brain workings and nerves
    Enzymes and synthesis
    Synapses
    receptors
    habituation
    half life of radioactive compounds
    role of neurotransmitters

    HSW
    Nature/nurture

    Pain and Gender
    testing procedure and progression of medicine
    types of studies (twin studies etc)
    hormones
    impulses and transmission
    nervous system in general
    types of brain scans

    HSW
    ethics
    variables
    nature/nurture
    culture

    hope it helps!
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    hey,
    are you all going to be doing any past papers(old syllabus) for this unit?
    or just do the questions in the textbook?
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    (Original post by Nearing Insanity)
    hey,
    are you all going to be doing any past papers(old syllabus) for this unit?
    or just do the questions in the textbook?
    Doing (well planning to do) past papers, I hate the book questions/snab sheets personally!
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    (Original post by skotch)
    Ok here are the questions our teacher set us about the pre-release material, as promised.

    1. Describe how a neurone can make a muscle 'clench'. (paragraph 3). (3)

    2. In para 6, what would make a simple 'neural circuit'? Draw a labelled diagram to help you. (3)

    3. What are the key issues, both positive and negative, of using animals in experiments to test (para 8) scientific theories of how the human body works? (4)

    4. In para 10, it describes how some neurones are excitatory, whilst others are inhibitory. Explain how this can be the case. (3)

    5. Describe the basic steps involved in inserting a gene (para 17) from rats into fruit flies. (4)

    6. The ChR2 gene codes for a channel protein (para 22). Describe how a channel protein works. (2)

    7. In para 23 a German team managed to express the ChR2 gene. Draw a simple flow chart showing the steps at a cellular level of how genes can be expressed. (3)

    8. Gottschalk (para 26) describes it as a 'proof of concept'. what does this mean? (2)

    9. In para 29 'action potentials are generated'. Describe how this occurs. (3)

    10. Deisseroth's clinical trial (para 36) was looking at area 25 of the limbic system. Discuss the validity of his results.

    11. Gene therapy involves a modified cold virus to insert the foreign gene (para 39). Why are viruses often used as vectors in gene therapy? (2)

    12. Apart from stress (para 43), what are the other key risk factors for cardiovascular disease? (4)

    13. How does the body prevent a neurone from repeatedly firing (para 50)? (3)

    14. What evidence suggests that noradrenaline is not the cause of stress (para 58)? (2)

    15. Why is it important that women should be included in clinical trials (para 67), and why are women often not included in such trials? (3)

    16. Summarise the key findings about why there seems to be sex differences in pain perception (from para 61 onwards). (5)

    17. Why might eating chillis make women suffer more pain than those who don't (para 78)? (1)

    N.B. "para" means paragraph and the number in brackets is the number of marks. Also, for question 4, in my textbook it doesn't have anything about excitatory/inhibitory neurones, just excitatory/inhibitory synapses, so I took it to mean the same thing.

    Hope this helps!

    Answers
    thank you so much for this!
    btw, this thread has helped me more than my teacher has
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    (Original post by 2089170)
    here
    these are realy good ques. did u get the answers for them?
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    Can someone please define & explain the following to me:
    Low critical temperature
    Low lethal temperature
    High critical temperature

    Thanks in advance!
 
 
 
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