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    Hey guys,


    Now before I begin my long list of questions, I wish to tell you that I tried my utmost hardest to search and complete this myself however seeing as a last resort I thought I'd roam through the great threads of TSR in an attempt to salvage somewhat of the pride I hold in front of my biology teacher. D:

    I'm doing my Edexcel Bio coursework and I chose CJD and how the diagnosis for it got faster but I can't for the life of me find substantial information on exactly how the diagnosis got faster. Could anyone help me out please? I mean I know that they use MRI, EEG, spinal tap etc etc..

    Also, do you think using opiates to relieve CJD symptoms is an ethical issue? Anything else an ethical issue regarding how CJD is diagnosed?

    I would also appreciate it if there were any graphics or charts related to CJD as I've been searching Google but I can't seem to find anything that I would call a 'reliable' enough source to add to my bibliography. I dunno something like a comaprison between a normal, healthy brain and a brain affected by CJD.

    Please and thank you I'd offer the most helpful member a box of Thorntons and a bottle of Pepsi but that'd require me to actually find a job, earn some cash, and FedEx it to you (depends where you live LOL)



    /panicrantconglomerationramblings yadaydaydayfjkfdksfs;' I'm dying.


    Life sucks when you've to complete this like...soonish.
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    (Original post by Confusing_Chem)
    Hey guys,


    Now before I begin my long list of questions, I wish to tell you that I tried my utmost hardest to search and complete this myself however seeing as a last resort I thought I'd roam through the great threads of TSR in an attempt to salvage somewhat of the pride I hold in front of my biology teacher. D:

    I'm doing my Edexcel Bio coursework and I chose CJD and how the diagnosis for it got faster but I can't for the life of me find substantial information on exactly how the diagnosis got faster. Could anyone help me out please? I mean I know that they use MRI, EEG, spinal tap etc etc..

    Also, do you think using opiates to relieve CJD symptoms is an ethical issue? Anything else an ethical issue regarding how CJD is diagnosed?

    I would also appreciate it if there were any graphics or charts related to CJD as I've been searching Google but I can't seem to find anything that I would call a 'reliable' enough source to add to my bibliography. I dunno something like a comaprison between a normal, healthy brain and a brain affected by CJD.

    Please and thank you I'd offer the most helpful member a box of Thorntons and a bottle of Pepsi but that'd require me to actually find a job, earn some cash, and FedEx it to you (depends where you live LOL)



    /panicrantconglomerationramblings yadaydaydayfjkfdksfs;' I'm dying.


    Life sucks when you've to complete this like...soonish.
    Here are a few papers for you to have a read of for starters:

    http://www.pnas.org/content/102/9/3501.short (Safar, et al. 2004. Diagnosis of human prion disease.)

    http://pubs.acs.org/doi/abs/10.1021/pr800832s (Herbst, et al. 2009. Prion disease Diagnosis by Proteomic Profiling.)

    http://brain.oxfordjournals.org/cont.../10/2669.short (Lodi et al. 2009. MR diagnostic markers in sporadic prion disease.)

    http://dx.doi.org/10.1016/S0140-6736(10)62308-2 (Edgeworth et al. 2011. Detection of prion infection in vCJD - a blood based assay). <--This paper was pretty topical and made the news last month because a blood based screen like this is a big step forward for rapid, reliable diagnosis.

    If you need access to the full papers (although the abstract is normally quite sufficient at this level) let me know and I can send them to you. Feel free to ask if you need any aspects of the papers explained to you.

    As for pictures, here's quite a nice one: http://medicalimages.allrefer.com/la...ob-disease.jpg

    This one also shows a little of the molecular mechanism: http://www.indmedica.com/journals/im...2_01_Fig01.jpg

    For more stuff, I'd recommend googling for 'prion disease' or 'spongiform encephalopathy' followed by 'diagnosis' or 'screening' or 'histology', etc.
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    (Original post by Revd. Mike)
    Here are a few papers for you to have a read of for starters:

    http://www.pnas.org/content/102/9/3501.short (Safar, et al. 2004. Diagnosis of human prion disease.)

    http://pubs.acs.org/doi/abs/10.1021/pr800832s (Herbst, et al. 2009. Prion disease Diagnosis by Proteomic Profiling.)

    http://brain.oxfordjournals.org/cont.../10/2669.short (Lodi et al. 2009. MR diagnostic markers in sporadic prion disease.)

    http://dx.doi.org/10.1016/S0140-6736(10)62308-2 (Edgeworth et al. 2011. Detection of prion infection in vCJD - a blood based assay). <--This paper was pretty topical and made the news last month because a blood based screen like this is a big step forward for rapid, reliable diagnosis.

    If you need access to the full papers (although the abstract is normally quite sufficient at this level) let me know and I can send them to you. Feel free to ask if you need any aspects of the papers explained to you.

    As for pictures, here's quite a nice one: http://medicalimages.allrefer.com/la...ob-disease.jpg

    This one also shows a little of the molecular mechanism: http://www.indmedica.com/journals/im...2_01_Fig01.jpg

    For more stuff, I'd recommend googling for 'prion disease' or 'spongiform encephalopathy' followed by 'diagnosis' or 'screening' or 'histology', etc.
    Thanks so much!!

    http://linkinghub.elsevier.com/retri...40673610623082

    could you possibly find me the full article please?
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    I have it as a PDF. Technically, as it's copyright material I can't attach it here. If you PM me your email address I'll send it to you.
 
 
 
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