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    So it needs TCR interaction with MHC, AND costimulation of its CD28 (by B7) or CD40L (by CD40). Are B7 and CD40 only expressed on the APC when there is a pathogen signal or something? I'm reading that "Co-stimulation is induced by "danger signal" - e.g. PAMP - TLR"... is it that a PAMP will cause the APC to express B7 or CD40?
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    (Original post by Calumcalum)
    So it needs TCR interaction with MHC, AND costimulation of its CD28 (by B7) or CD40L (by CD40). Are B7 and CD40 only expressed on the APC when there is a pathogen signal or something? I'm reading that "Co-stimulation is induced by "danger signal" - e.g. PAMP - TLR"... is it that a PAMP will cause the APC to express B7 or CD40?
    I'm a little rusty on my immunology, it's been a year since I've studied it and I'm currently working in neuroscience, so it's all a bit vague

    I'm fairly sure that the costimulatory molecules are expressed as a result of TLR activation by PAMPs. I'll dig my notes out later and confirm, but I'm pretty sure that's the case.
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    (Original post by Revd. Mike)
    I'm a little rusty on my immunology, it's been a year since I've studied it and I'm currently working in neuroscience, so it's all a bit vague

    I'm fairly sure that the costimulatory molecules are expressed as a result of TLR activation by PAMPs. I'll dig my notes out later and confirm, but I'm pretty sure that's the case.
    Thanks a lot! I know the feeling - I've pretty much moved fully into neuro now; the only problem is, I haven't taken my Pathology or Physiology exams yet
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    Yeah you guys have pretty much got it. Toll-like receptor on the APC is activated by a danger signal (e.g. PAMP) - the activated APC upregulates the necessary TCR ligands and costimulatory molecules and migrates to the lymphoid tissue where it presents them to naive T-cells
 
 
 
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